Abstract
The present paper discusses models of 5-HT1A and 5-HT2A receptors, developed by conformational analysis and 3D-QSAR methods. Hypotheses concerning the ligand-5-HT7 receptor interaction were complemented by models constructed on the basis of the receptor's structure. Various pharmacophore concepts are supported by structures of exemplary ligands and groups of compounds, derived from chain polycyclic arylpiperazines, used for models generations.
Keywords: arylpiperazine, pharmacophore model, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor.
Mini-Reviews in Medicinal Chemistry
Title:Computational Methods in Determination of Pharmacophore Models of 5-HT1A, 5-HT2A and 5-HT7 Receptors
Volume: 13 Issue: 7
Author(s): Anna Bielenica, Anna E. Koziol and Marta Struga
Affiliation:
Keywords: arylpiperazine, pharmacophore model, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor.
Abstract: The present paper discusses models of 5-HT1A and 5-HT2A receptors, developed by conformational analysis and 3D-QSAR methods. Hypotheses concerning the ligand-5-HT7 receptor interaction were complemented by models constructed on the basis of the receptor's structure. Various pharmacophore concepts are supported by structures of exemplary ligands and groups of compounds, derived from chain polycyclic arylpiperazines, used for models generations.
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Cite this article as:
Bielenica Anna, E. Koziol Anna and Struga Marta, Computational Methods in Determination of Pharmacophore Models of 5-HT1A, 5-HT2A and 5-HT7 Receptors, Mini-Reviews in Medicinal Chemistry 2013; 13 (7) . https://dx.doi.org/10.2174/1389557511313070001
DOI https://dx.doi.org/10.2174/1389557511313070001 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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