Abstract
Although the physiological function of sleep is not completely understood, it is well documented that it contributes significantly to the process of learning and memory. Ample evidence suggests that adequate sleep is essential for fostering connections among neuronal networks for memory consolidation in the hippocampus. Sleep deprivation studies are extremely valuable in understanding why we sleep and what are the consequences of sleep loss. Experimental sleep deprivation in animals allows us to gain insight into the mechanism of sleep at levels not possible to study in human subjects. Many useful approaches have been utilized to evaluate the effect of sleep loss on cognitive function, each with relative advantages and disadvantages. In this review we discuss sleep and the detrimental effects of sleep deprivation mostly in experimental animals. The negative effects of sleep deprivation on various aspects of brain function including learning and memory, synaptic plasticity and the state of cognition-related signaling molecules are discussed.
Keywords: Modified Multiple Platform, LTP, LTD, electrophysiology, anxiety, neurogenesis, nicotine, exercise.
Current Neuropharmacology
Title:Neurobiological Consequences of Sleep Deprivation
Volume: 11 Issue: 3
Author(s): Karim Alkadhi, Munder Zagaar, Ibrahim Alhaider, Samina Salim and Abdulaziz Aleisa
Affiliation:
Keywords: Modified Multiple Platform, LTP, LTD, electrophysiology, anxiety, neurogenesis, nicotine, exercise.
Abstract: Although the physiological function of sleep is not completely understood, it is well documented that it contributes significantly to the process of learning and memory. Ample evidence suggests that adequate sleep is essential for fostering connections among neuronal networks for memory consolidation in the hippocampus. Sleep deprivation studies are extremely valuable in understanding why we sleep and what are the consequences of sleep loss. Experimental sleep deprivation in animals allows us to gain insight into the mechanism of sleep at levels not possible to study in human subjects. Many useful approaches have been utilized to evaluate the effect of sleep loss on cognitive function, each with relative advantages and disadvantages. In this review we discuss sleep and the detrimental effects of sleep deprivation mostly in experimental animals. The negative effects of sleep deprivation on various aspects of brain function including learning and memory, synaptic plasticity and the state of cognition-related signaling molecules are discussed.
Export Options
About this article
Cite this article as:
Alkadhi Karim, Zagaar Munder, Alhaider Ibrahim, Salim Samina and Aleisa Abdulaziz, Neurobiological Consequences of Sleep Deprivation, Current Neuropharmacology 2013; 11 (3) . https://dx.doi.org/10.2174/1570159X11311030001
DOI https://dx.doi.org/10.2174/1570159X11311030001 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis
Current Pharmaceutical Design Mechanisms of Platelet Activation in Acute Coronary Syndromes
Current Vascular Pharmacology Interplay between Catalysts and Substrates for Activity of Class Ib Aminoacyl-tRNA Synthetases and Implications for Pharmacology
Current Topics in Medicinal Chemistry The Importance of Selenium Biofortification in Food Crops
Current Nutrition & Food Science Identification of Potent Caspase-3 Inhibitors for Treatment of Multi- Neurodegenerative Diseases Using Pharmacophore Modeling and Docking Approaches
CNS & Neurological Disorders - Drug Targets Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology:Theory, Data Acquisition,Analysis, and Examples
Current Medical Imaging Meet Our Editorial Board Member
Anti-Cancer Agents in Medicinal Chemistry Redox Regulation and the Autistic Spectrum: Role of Tryptophan Catabolites, Immuno-inflammation, Autoimmunity and the Amygdala
Current Neuropharmacology Evaluation of Novel Substituted Furopyridines as Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer´s Disease
Medicinal Chemistry Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain
Current Drug Targets Mitogen Activated Protein (MAP) Kinases: Development of ATP and Non- ATP Dependent Inhibitors
Medicinal Chemistry The Potential of Embryonic Stem Cells Combined with -omics Technologies as Model Systems for Toxicology
Current Medicinal Chemistry Misoprostol Reverse Hippocampal Neuron Cyclooxygenase-2 Downstream Signaling Imbalance in Aluminum-Overload Rats
Current Alzheimer Research Relation of Obesity to Cognitive Function: Importance of Central Obesity and Synergistic Influence of Concomitant Hypertension. The Framingham Heart Study
Current Alzheimer Research The Translocator Protein 18 kDa (TSPO) and Its Role in Mitochondrial Biology and Psychiatric Disorders
Mini-Reviews in Medicinal Chemistry Mutations of mtDNA in some Vascular and Metabolic Diseases
Current Pharmaceutical Design Meet Our Editorial Board Member
CNS & Neurological Disorders - Drug Targets Retraction Notice: Microarray and Synchronization of Neuronal Differentiation with Pathway Changes in the Kyoto Encyclopedia of Genes and Genomes (KEGG) Databank in Nerve Growth Factor-Treated PC12 Cells
Current Neurovascular Research Herbal Highs: Review on Psychoactive Effects and Neuropharmacology
Current Neuropharmacology Feasibility of FDG PET in Inflammatory Bowel Disease
Current Molecular Imaging (Discontinued)