Abstract
Lipase inhibitors have generated a great interest because they could help in the prevention or the therapy of lipase‐related diseases. Therefore, the aim of this work was to evaluate the inhibitory effect of secondary metabolites extracts such as phenolic compounds and saponins of three Algerian medicinal plants: Achillea santolina, Inonotus hispidus and Zizyphus lotus, indeed their antiradicalaire activity using DPPH• (1, 1‐diphenyl‐2‐picryl‐hydrazyl). The phenolic extracts have shown a strong antiradicalaire activity than the saponin extracts with EC50 values ranged from 6 to 11 μg/ml and from 51 to 82 μg/ml, respectively. The enzymatic inhibition produced by these plant extracts is described here for the first time. The results have shown that the phenolic extracts are more potent than the saponin extracts with Ki values ranged from 0.011 mg/ml to 0.027 mg/ml for phenolic extracts, and ranged from 0.071 mg/ml to 0.69 mg/ml for saponin extracts. The nature, mechanism and possible physiological relevance of lipase inhibition by extract components are discussed.
Keywords: Achillea santolina, Inonotus hispidus, Zizyphus lotus, Candida rugosa lipase, inhibition, saponins extracts, phenolic extracts, DPPH•.
Current Enzyme Inhibition
Title:Inhibition of Candida rugosa Lipase by Secondary Metabolites Extracts of Three Algerian Plants and their Antioxydant Activities
Volume: 9 Issue: 1
Author(s): K. Benarous, A. Djeridane, A. Kameli and M. Yousfi
Affiliation:
Keywords: Achillea santolina, Inonotus hispidus, Zizyphus lotus, Candida rugosa lipase, inhibition, saponins extracts, phenolic extracts, DPPH•.
Abstract: Lipase inhibitors have generated a great interest because they could help in the prevention or the therapy of lipase‐related diseases. Therefore, the aim of this work was to evaluate the inhibitory effect of secondary metabolites extracts such as phenolic compounds and saponins of three Algerian medicinal plants: Achillea santolina, Inonotus hispidus and Zizyphus lotus, indeed their antiradicalaire activity using DPPH• (1, 1‐diphenyl‐2‐picryl‐hydrazyl). The phenolic extracts have shown a strong antiradicalaire activity than the saponin extracts with EC50 values ranged from 6 to 11 μg/ml and from 51 to 82 μg/ml, respectively. The enzymatic inhibition produced by these plant extracts is described here for the first time. The results have shown that the phenolic extracts are more potent than the saponin extracts with Ki values ranged from 0.011 mg/ml to 0.027 mg/ml for phenolic extracts, and ranged from 0.071 mg/ml to 0.69 mg/ml for saponin extracts. The nature, mechanism and possible physiological relevance of lipase inhibition by extract components are discussed.
Export Options
About this article
Cite this article as:
Benarous K., Djeridane A., Kameli A. and Yousfi M., Inhibition of Candida rugosa Lipase by Secondary Metabolites Extracts of Three Algerian Plants and their Antioxydant Activities, Current Enzyme Inhibition 2013; 9 (1) . https://dx.doi.org/10.2174/1573408011309010010
DOI https://dx.doi.org/10.2174/1573408011309010010 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chromogranins and Inositol 1,4,5-Trisphosphate-Dependent Ca2+-Signaling in Cardiomyopathy and Heart Failure
Current Medicinal Chemistry Recent Progress and Related Patents on the Applications of Bone Marrow-Derived Stem/Progenitor Cells in Regenerative Medicine and Cancer Therapies
Recent Patents on Regenerative Medicine Editorial (Thematic Issue: Novel Data on the Pathogenesis of Atherosclerosis, Treatment Targets, and New Therapeutic Interventions in Lipid-Related Cardiovascular Risk Factors)
Current Pharmaceutical Design Pharmacological manipulation of peripheral vascular resistance in special clinical situations after pediatric cardiac surgery
Current Vascular Pharmacology Clinical Use of Neurophysiological Biomarkers and Self-Assessment Scales to Predict and Monitor Treatment Response for Psychotic and Affective Disorders
Current Pharmaceutical Design Angiotensin Converting Enzyme (ACE) Inhibitory Peptides: Production and Implementation of Functional Food
Current Pharmaceutical Design Restless Legs Syndrome in Multiple Sclerosis
CNS & Neurological Disorders - Drug Targets Treating Heart Failure with Preserved Ejection Fraction Related to Arterial Stiffness. Can we Kill Two Birds With One Stone?
Current Vascular Pharmacology The Diagnosis of Large Airway Pathology and the Role of Rigid Bronchoscopy
Current Respiratory Medicine Reviews Editorial (Thematic Issue: Targeting Cell Death and Proliferation Receptors in Cancer)
Current Pharmaceutical Design Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty Acid
Current Pharmaceutical Biotechnology Left Ventricular Hypertrophy and Angiotensin II Receptor Blocking Agents
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Transforming Growth Factor β Signaling Perturbation in the Loeys-Dietz Syndrome
Current Medicinal Chemistry Nitric Oxide and Dietary Factors: Part III Minerals, Vitamins and Other Dietary and Lifestyle Factors
Vascular Disease Prevention (Discontinued) Anti-Biofilm Strategies and the Need for Innovations in Wound Care
Recent Patents on Anti-Infective Drug Discovery Understanding Genetic Factors in Idiopathic Scoliosis, a Complex Disease of Childhood
Current Genomics Sirtuins: Possible Clinical Implications in Cardio and Cerebrovascular Diseases
Current Drug Targets Preparation and Characterization of Water-soluble and Highly Fluorescent Biopolymer-conjugated CdS Quantum Dots
Current Nanoscience Interventions to Reduce Cardiovascular Risk in Children with Type 1 Diabetes
Current Diabetes Reviews Statin Therapy-Evidence Beyond Lipid Lowering Contributing to Plaque Stability
Current Medicinal Chemistry