Abstract
One potential mechanism for the effectiveness of organoselenium compounds against a number of cancer cell lines is the interaction of selenium with zinc signaling processes. Reducible selenium (rSe) compounds such as diselenides, selenenyl halides and seleninic acids release zinc from zinc fingers and metallothionein. Based upon a review of the literature, two key mechanisms are discussed: the stoichiometric displacement of zinc by selenium and the catalytic oxidation of Cys thiolates by reducible organoselenium compounds produced in situ. Initial DFT calculations of the strengths of interactions between rSe and a Cys2His2-type ZF model are presented to contrast the reactivity of reducible selenium compounds with sulfur and tellurium analogues.
Keywords: Selenium, zinc finger proteins, zinc signaling, cancer prevention, density-functional theory, molecular modeling
Current Chemical Biology
Title:Oxidation of Zinc-Sulfur Centers by Reducible Organoselenium Compounds: A Review and Bonding Perspective
Volume: 7 Issue: 1
Author(s): Craig A. Bayse, Sean M. Whitty and Sonia Antony
Affiliation:
Keywords: Selenium, zinc finger proteins, zinc signaling, cancer prevention, density-functional theory, molecular modeling
Abstract: One potential mechanism for the effectiveness of organoselenium compounds against a number of cancer cell lines is the interaction of selenium with zinc signaling processes. Reducible selenium (rSe) compounds such as diselenides, selenenyl halides and seleninic acids release zinc from zinc fingers and metallothionein. Based upon a review of the literature, two key mechanisms are discussed: the stoichiometric displacement of zinc by selenium and the catalytic oxidation of Cys thiolates by reducible organoselenium compounds produced in situ. Initial DFT calculations of the strengths of interactions between rSe and a Cys2His2-type ZF model are presented to contrast the reactivity of reducible selenium compounds with sulfur and tellurium analogues.
Export Options
About this article
Cite this article as:
A. Bayse Craig, M. Whitty Sean and Antony Sonia, Oxidation of Zinc-Sulfur Centers by Reducible Organoselenium Compounds: A Review and Bonding Perspective, Current Chemical Biology 2013; 7 (1) . https://dx.doi.org/10.2174/2212796811307010006
DOI https://dx.doi.org/10.2174/2212796811307010006 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Novel Drugs Targeting the c-Ring of the F<sub>1</sub>F<sub>O</sub>-ATP Synthase
Mini-Reviews in Medicinal Chemistry EBV-Associated Tumors: Pathogenetic Insights for Improved Disease Monitoring and Treatment
Current Cancer Therapy Reviews Role of CHK2 Inhibitors in the Cellular Responses to Ionizing Radiation
Mini-Reviews in Medicinal Chemistry Pioglitazone and Cancer: Angel or Demon?
Current Pharmaceutical Design Novel Therapeutics Against Breast Cancer Stem Cells by Targeting Surface Markers and Signaling Pathways
Current Stem Cell Research & Therapy Antiangiogenic Therapy
Current Pharmaceutical Design Nanoparticulate Drug Delivery to Colorectal Cancer: Formulation Strategies and Surface Engineering
Current Pharmaceutical Design State-of-the-art MR Imaging of Uncommon Hepatocellular Tumours: Fibrolamellar Hepatocellular Carcinoma and Combined Hepatocellularcholangiocarcinoma
Current Medical Imaging Targeting the Immune Niche within the Bone Marrow Microenvironment: The Rise of Immunotherapy in Multiple Myeloma
Current Cancer Drug Targets The Proteasome in Health and Disease
Current Pharmaceutical Design <i>In Silico</i> Designing a Novel Multi-epitope DNA Vaccine against Anti-apoptotic Proteins in Tumor Cells
Current Proteomics RNA-Mediated Therapeutics: From Gene Inactivation to Clinical Application
Current Topics in Medicinal Chemistry Wnt/β-Catenin/LEF-1 Signaling in Chronic Lymphocytic Leukemia (CLL): A Target for Current and Potential Therapeutic Options
Current Cancer Drug Targets Effect of Curcumin on Pro-angiogenic Factors in the Xenograft Model of Breast Cancer
Anti-Cancer Agents in Medicinal Chemistry A Systems Biology Approach for miRNA-mRNA Expression Patterns Analysis in Rheumatoid Arthritis
Combinatorial Chemistry & High Throughput Screening Bioactive Secondary Metabolites from Endophytic Fungi
Current Medicinal Chemistry Bis(2-aminoimidazolines) and Bisguanidines: Synthetic Approaches, Antiparasitic Activity and DNA Binding Properties
Current Medicinal Chemistry Tackling Cardiovascular Risk: New Evidence from Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Metabolic Changes in Cancer Patients
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Thyroid Hormone Levels in the Prefrontal Cortex of Post-Mortem Brains of Alzheimers Disease Patients
Current Aging Science