Abstract
In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds were elucidated by 1H-NMR and mass spectral data and elemental analysis. The compounds were screened for their antimicrobial activities against pathogenic bacteria and Candida species. The compounds were also investigated for their cytotoxic properties using MTT assay. The microbiological results revealed that the compounds were more effective against fungi than bacteria. Among Candida species, C. utilis was the most susceptible fungus to compounds 7 and 11. It is apparent that 2,6-dimethylpiperidine group and chloro and methyl substituents on benzothiazole ring have an important impact on anticandidal activity. MTT assay indicated that the effective doses of these derivatives were lower than their cytotoxic doses.
Keywords: Amide, Benzothiazole, Piperidine, Antimicrobial activity, Cytotoxicity
Letters in Drug Design & Discovery
Title:Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents
Volume: 10 Issue: 5
Author(s): Mehlika Dilek Altintop, Ahmet Ozdemir, Zafer Asim Kaplancikli, Gulhan Turan-Zitouni, Gokalp Iscan and Gulsen Akalin Ciftci
Affiliation:
Keywords: Amide, Benzothiazole, Piperidine, Antimicrobial activity, Cytotoxicity
Abstract: In this study, N-(benzothiazol-2-yl)-2-(piperidin-1-yl)acetamide derivatives (1-24) were obtained by the reaction of 2-chloro-N-(benzothiazole-2-yl)acetamides with piperidine derivatives. The structures of the compounds were elucidated by 1H-NMR and mass spectral data and elemental analysis. The compounds were screened for their antimicrobial activities against pathogenic bacteria and Candida species. The compounds were also investigated for their cytotoxic properties using MTT assay. The microbiological results revealed that the compounds were more effective against fungi than bacteria. Among Candida species, C. utilis was the most susceptible fungus to compounds 7 and 11. It is apparent that 2,6-dimethylpiperidine group and chloro and methyl substituents on benzothiazole ring have an important impact on anticandidal activity. MTT assay indicated that the effective doses of these derivatives were lower than their cytotoxic doses.
Export Options
About this article
Cite this article as:
Dilek Altintop Mehlika, Ozdemir Ahmet, Asim Kaplancikli Zafer, Turan-Zitouni Gulhan, Iscan Gokalp and Akalin Ciftci Gulsen, Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents, Letters in Drug Design & Discovery 2013; 10 (5) . https://dx.doi.org/10.2174/1570180811310050013
DOI https://dx.doi.org/10.2174/1570180811310050013 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Enhanced Proliferation and Osteogenic Differentiation of Human Umbilical Cord Blood Stem Cells by L-Ascorbic Acid, In Vitro
Current Stem Cell Research & Therapy Biomaterial Scaffolds for Mesenchymal Stem Cell Based Therapy Aimed at Tissue Engineering Application for Osteoarthritis
Recent Patents on Nanomedicine Brain-Delivery of Zinc-Ions as Potential Treatment for Neurological Diseases: Mini Review
Drug Delivery Letters Minocycline: Neuroprotective Mechanisms in Parkinsons Disease
Current Pharmaceutical Design Therapeutic Exploitation of Endogenous Anti-Inflammatory Mechanisms:Old and New Leads
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Anatomical and Functional Relationships Between Sensory Nerves and Mast Cells
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Wound Healing Agents: The Role of Natural and Non-Natural Products in Drug Development
Mini-Reviews in Medicinal Chemistry Central Regulatory Role of Cytokines in Periodontitis and Targeting Options
Current Medicinal Chemistry Stable Gastric Pentadecapeptide BPC 157: Novel Therapy in Gastrointestinal Tract
Current Pharmaceutical Design Cubic Phases, Cubosomes and Ethosomes for Cutaneous Application
Current Pharmaceutical Design Thrombomodulin Links Coagulation to Inflammation and Immunity
Current Drug Targets Tailoring an Antibacterial Peptide of Human Lysosomal Cathepsin G to Enhance its Broad-Spectrum Action Against Antibiotic-Resistant Bacterial Pathogens
Current Pharmaceutical Design Anti-Oxidative Polyphenolic Compounds of Cocoa
Current Pharmaceutical Biotechnology A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense
Current Respiratory Medicine Reviews Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine
Current Pharmacogenomics and Personalized Medicine The Janus Face of Cathelicidin in Tumorigenesis
Current Medicinal Chemistry Drug Interactions During Periodontal Therapy in HIV-Infected Subjects
Mini-Reviews in Medicinal Chemistry Inflammaging and Proteases in Abdominal Aortic Aneurysm
Current Vascular Pharmacology Glia-Driven Neuroinflammation and Systemic Inflammation in Alzheimer’s Disease
Current Neuropharmacology Development of Denticap, a Matrix Based Sustained Release Formulation for Treatment of Toothache, Dental Infection and Other Gum Problem
Current Drug Delivery