Abstract
In this paper, a recently reported series of NPS antagonists is further expanded and biologically evaluated. The ligand efficiency and ADMET score concepts were then applied to the newly disclosed 5-phenyl-2-[2-(1-piperidinylcarbonyl) phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones, to limit the SAR exploration. Important pharmacophoric features were identified suggesting potential way forward for the identification of further developable templates.
Keywords: ADMET score, Ligand efficiency, NPS antagonists, Pharmacophore features
Letters in Drug Design & Discovery
Title:Further Insights in 5-phenyl-2-[2-(1-piperidinylcarbonyl) Phenyl]-2,3- dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones, a Recently Disclosed Class of Neuropeptide S Antagonists
Volume: 10 Issue: 5
Author(s): Adelheid Roth, Anna Maria Capelli, Raffaele Longhi, Federica Tonelli, Luca Tarsi, Dino Montanari, Giorgio Bonanomi, Matteo Biagetti, Emilio Merlo-Pich, Gabriele Costantino, Angelo Giacometti, Romano Di Fabio, Angela Worby, Fabrizio Micheli, Elisa Della Turca, Gian Paolo Vallerini, Chiara Pecchini and Marco Mor
Affiliation:
Keywords: ADMET score, Ligand efficiency, NPS antagonists, Pharmacophore features
Abstract: In this paper, a recently reported series of NPS antagonists is further expanded and biologically evaluated. The ligand efficiency and ADMET score concepts were then applied to the newly disclosed 5-phenyl-2-[2-(1-piperidinylcarbonyl) phenyl]-2,3-dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones, to limit the SAR exploration. Important pharmacophoric features were identified suggesting potential way forward for the identification of further developable templates.
Export Options
About this article
Cite this article as:
Roth Adelheid, Maria Capelli Anna, Longhi Raffaele, Tonelli Federica, Tarsi Luca, Montanari Dino, Bonanomi Giorgio, Biagetti Matteo, Merlo-Pich Emilio, Costantino Gabriele, Giacometti Angelo, Di Fabio Romano, Worby Angela, Micheli Fabrizio, Della Turca Elisa, Paolo Vallerini Gian, Pecchini Chiara and Mor Marco, Further Insights in 5-phenyl-2-[2-(1-piperidinylcarbonyl) Phenyl]-2,3- dihydro-1H-pyrrolo[1,2-c]imidazol-1-ones, a Recently Disclosed Class of Neuropeptide S Antagonists, Letters in Drug Design & Discovery 2013; 10 (5) . https://dx.doi.org/10.2174/1570180811310050005
DOI https://dx.doi.org/10.2174/1570180811310050005 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current Advancements in Aβ Luminescent Probes and Inhibitors of Aβ Aggregation
Current Alzheimer Research SARS-CoV-2 and its Predicted Potential Natural Inhibitors: A Review and Perspective
Coronaviruses Microwave Assisted Synthesis of Imidazoles - A Review
Mini-Reviews in Organic Chemistry Modern Developments in the Spray-Drying Industries
Recent Patents on Materials Science Cysteine Protease Inhibitors: from Evolutionary Relationships to Modern Chemotherapeutic Design for the Treatment of Infectious Diseases
Current Protein & Peptide Science Avian Flu; Pathogenesis and Therapy
Anti-Infective Agents Common Bile Duct Obstructed by Lipiodol After Transcater Arterial Chemoembolization for Hepatocellular Carcinoma: A Case Report
Current Medical Imaging Chiral Kinase Inhibitors
Current Topics in Medicinal Chemistry The Role of Justicia adhatoda as Prophylaxis for COVID-19 – Analysis Based on Docking
Infectious Disorders - Drug Targets G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application
Current Pharmaceutical Design Modeling and Informatics in Designing Anti-Diabetic Agents
Current Pharmaceutical Design Computational Biology in Anti-Tuberculosis Drug Discovery
Infectious Disorders - Drug Targets Current Applications of Therapeutic Gases in Neonatal Intensive Care
Current Pediatric Reviews Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents
Letters in Drug Design & Discovery Design, Synthesis, and Transport Potential of a New Family of Nonionic Amphiphilic Dendro-calix[4]arene
Current Organic Chemistry COVID-19: Potential Repurposing Drugs
Infectious Disorders - Drug Targets Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
Current Pharmaceutical Design Rates of Anxiety, Depression, and Stress Among High School Students During the COVID-19 Pandemic
Current Psychiatry Research and Reviews Exploring Quantitative Nanostructure-Activity Relationships (QNAR) Modeling as a Tool for Predicting Biological Effects of Manufactured Nanoparticles
Combinatorial Chemistry & High Throughput Screening Subject Index to Volume 1
Current Medicinal Chemistry - Cardiovascular & Hematological Agents