Abstract
Plasmalogens are unique vinyl ether glycerophospholipids that serve diverse structural roles in the membranes of cells and cell organelles. Additionally, the fatty acid substitutions at sn– 2 of the glycerol backbone are dynamically removed by lipases and replaced by acyltransferases. These fatty acid storage pools provide the free arachidonic acid and docosahexaenoic acid (DHA) involved in signal transduction cascades.
The biosynthesis of plasmalogens critically involves the generation of the ether lipid substitution at sn–1 of the glycerol backbone. This step only occurs in peroxisomes and is dysfunctional in genetic peroxisomal disorders and in several diseases of aging.
A number of approaches have been undertaken to augment plasmalogen levels in these clinical conditions. In this review we present the current status of alkylglycerol precursors that bypass the requirement of the peroxisomal compartment.
Keywords: Alkylglycerol, Ecomer, krill oil, DHA, plasmalogen, peroxisome.
Current Organic Chemistry
Title:Alkylglycerol Lipid Precursors: A Review of Therapeutic Strategies for Plasmalogen Replacement
Volume: 17 Issue: 8
Author(s): Paul L. Wood
Affiliation:
Keywords: Alkylglycerol, Ecomer, krill oil, DHA, plasmalogen, peroxisome.
Abstract: Plasmalogens are unique vinyl ether glycerophospholipids that serve diverse structural roles in the membranes of cells and cell organelles. Additionally, the fatty acid substitutions at sn– 2 of the glycerol backbone are dynamically removed by lipases and replaced by acyltransferases. These fatty acid storage pools provide the free arachidonic acid and docosahexaenoic acid (DHA) involved in signal transduction cascades.
The biosynthesis of plasmalogens critically involves the generation of the ether lipid substitution at sn–1 of the glycerol backbone. This step only occurs in peroxisomes and is dysfunctional in genetic peroxisomal disorders and in several diseases of aging.
A number of approaches have been undertaken to augment plasmalogen levels in these clinical conditions. In this review we present the current status of alkylglycerol precursors that bypass the requirement of the peroxisomal compartment.
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Cite this article as:
Wood Paul L., Alkylglycerol Lipid Precursors: A Review of Therapeutic Strategies for Plasmalogen Replacement, Current Organic Chemistry 2013; 17 (8) . https://dx.doi.org/10.2174/1385272811317080004
DOI https://dx.doi.org/10.2174/1385272811317080004 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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