Transition Metal-Catalyzed Efficient and Green Transformations of P(O)-H Compounds to Functional Organophosphorus Compounds

Title:Transition Metal-Catalyzed Efficient and Green Transformations of P(O)-H Compounds to Functional Organophosphorus Compounds

Volume: 13 Issue: 6

Author(s): Qing Xu, Yong-Bo Zhou, Chang-Qiu Zhao, Shuang-Feng Yin and Li-Biao Han

Affiliation:

Keywords: Transition metal catalyst, P(O)-H compound, carbon-carbon unsaturated compound, regio- and stereoselective addition, carbon-H and heteroatom-H compounds, dehydrogenative coupling reactions, well-defined functional organophosphorus compound

Abstract: Organophosphorus compounds are of high importance in organic synthesis, catalysis, biochemistry, pharmaceuticals, and material science. In this mini review, we summarize our recent studies on transition metal-catalyzed green and atom efficient transformations of P(O)-H bonds to various versatile organophosphorus compounds, including the highly regio- and stereoselective P(O)-H additions to carbon-carbon unsaturated compounds, asymmetric hydrophosphorylation reactions, and dehydrogenative coupling reactions of P(O)-H compounds with carbon-H and heteroatom-H compounds. These new reactions provide efficient, general and practical ways for the preparation of a variety of well-defined functional organophosphorus compounds. Mechanistic aspects related to the catalytic processes are also discussed.

Cite this article as:

Xu Qing, Zhou Yong-Bo, Zhao Chang-Qiu, Yin Shuang-Feng and Han Li-Biao, Transition Metal-Catalyzed Efficient and Green Transformations of P(O)-H Compounds to Functional Organophosphorus Compounds, Mini-Reviews in Medicinal Chemistry 2013; 13 (6) . https://dx.doi.org/10.2174/1389557511313060005