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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Insight into the Medicinal Chemistry of the Endocannabinoid Hydrolase Inhibitors

Author(s): C.N. Kapanda, J.H. Poupaert and D.M. Lambert

Volume 20, Issue 14, 2013

Page: [1824 - 1846] Pages: 23

DOI: 10.2174/09298673113209990108

Price: $65

Abstract

Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.

Keywords: Endocannabinoid hydrolases, inhibitors, design, chemical structures, inhibition mechanism, structure-activity relationships.


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