Structural Features of Small Molecule Amyloid-Beta Self-Assembly Inhibitors

Title:Structural Features of Small Molecule Amyloid-Beta Self-Assembly Inhibitors

Volume: 9 Issue: 1

Author(s): Bela Torok, Seema Bag, Madhura Sarkar, Sujaya Dasgupta and Marianna Torok

Affiliation:

Keywords: Alzheimer’s disease, amyloid, amyloid-beta peptide, self-assembly, fibrils, oligomers, small molecule inhibitors, structure-activity relationship

Abstract: The role of various structural features, namely basic scaffolds and substituents of small molecule inhibitors of the self-assembly of amyloid-beta (Aβ) peptide, a key process in Alzheimer’s disease, is described. The literature analysis in this update extends to the past 5 years, thus the past 15 year period is covered. In addition, while our previous review was limited to anti-fibril agents the current update includes compounds with a major profile in oligomer inhibition as well, and covers inhibitors of the broadly defined Aβ self-assembly. Basis sets of 507 fibrillogenesis inhibitors and 154 oligomer formation inhibitors were surveyed and a chemical map of the inhibitors is provided highlighting the most common substituents that appear in these compounds.

Cite this article as:

Torok Bela, Bag Seema, Sarkar Madhura, Dasgupta Sujaya and Torok Marianna, Structural Features of Small Molecule Amyloid-Beta Self-Assembly Inhibitors, Current Bioactive Compounds 2013; 9 (1) . https://dx.doi.org/10.2174/1573407211309010006