Abstract
A series of new of 2-furano-4(3H)-quinazolinone derivatives 5 (a-t) were synthesized. The compounds were characterized by their IR, 1H NMR, 13C NMR, and Mass spectral data. The antimicrobial activity of newly anthranilic acid-based compounds against various bacteria; S. aureus, Salmonella enterica, Vibrio cholerae, Bacillus subtilis, Proteus mirabili, Escherichia coli V517, Mycobacterium smegmatics, Pseudomonas aeruginosa and fungi; C. albicans, were evaluated with ampicillin and amphotericin B as standards. All compounds were also evaluated for antibacterial activity against R. solanacearum along with Kocide 3000 as a commercialized reference. Compounds 5d, 5g, 5j, 5l, 5q, 5r, 5s, and 5t exhibited good potential as antimicrobial.
Keywords: Synthesis, Quinazolinone, Diamide (open quinazoline ring), Antimicrobial activity
Letters in Drug Design & Discovery
Title:Certain 2-Furano-4(3H)-Quinazolinone Analogs: Synthesis, Characterization and Pharmacological Evaluation
Volume: 10 Issue: 4
Author(s): Varun Bhardwaj, Poonam Sharma, Malleshappa N. Noolvi, Harun M. Patel, Sumit Bansal, Sandeep Lohan and Gaurav Badola
Affiliation:
Keywords: Synthesis, Quinazolinone, Diamide (open quinazoline ring), Antimicrobial activity
Abstract: A series of new of 2-furano-4(3H)-quinazolinone derivatives 5 (a-t) were synthesized. The compounds were characterized by their IR, 1H NMR, 13C NMR, and Mass spectral data. The antimicrobial activity of newly anthranilic acid-based compounds against various bacteria; S. aureus, Salmonella enterica, Vibrio cholerae, Bacillus subtilis, Proteus mirabili, Escherichia coli V517, Mycobacterium smegmatics, Pseudomonas aeruginosa and fungi; C. albicans, were evaluated with ampicillin and amphotericin B as standards. All compounds were also evaluated for antibacterial activity against R. solanacearum along with Kocide 3000 as a commercialized reference. Compounds 5d, 5g, 5j, 5l, 5q, 5r, 5s, and 5t exhibited good potential as antimicrobial.
Export Options
About this article
Cite this article as:
Bhardwaj Varun, Sharma Poonam, N. Noolvi Malleshappa, M. Patel Harun, Bansal Sumit, Lohan Sandeep and Badola Gaurav, Certain 2-Furano-4(3H)-Quinazolinone Analogs: Synthesis, Characterization and Pharmacological Evaluation, Letters in Drug Design & Discovery 2013; 10 (4) . https://dx.doi.org/10.2174/1570180811310040010
DOI https://dx.doi.org/10.2174/1570180811310040010 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Adamantane – A Lead Structure for Drugs in Clinical Practice
Current Medicinal Chemistry What is the Current Role for Vitamin D and the Risk of Stroke?
Current Neurovascular Research Design, Synthesis and Characterization of Novel Urolithin Derivatives as Cholinesterase Inhibitor Agents
Letters in Drug Design & Discovery Using Endogenous Neural Stem Cells to Enhance Recovery from Ischemic Brain Injury
Current Neurovascular Research Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences
Endocrine, Metabolic & Immune Disorders - Drug Targets IL-15 and HIV Infection: Lessons for Immunotherapy and Vaccination
Current HIV Research Agonist-Trafficking and Hallucinogens
Current Medicinal Chemistry Nitric Oxide Related Therapeutic Phenomenon: A Challenging Task
Current Pharmaceutical Design 6-Oxo-Morphinane Oximes: Pharmacology, Chemistry and Analytical Application
Current Medicinal Chemistry Current Targets for Anticancer Drug Discovery
Current Drug Targets The Application of Micro-Analytical Techniques to Biomedical Analysis
Current Pharmaceutical Analysis Editorial [ Hot topic: Aquaporins and Nervous System: from Bench to Bedside (Guest Editors: Rita Rezzani and Luigi F. Rodella) ]
Current Neuropharmacology Patent Selections
Recent Patents on CNS Drug Discovery (Discontinued) Pomegranate as a Possible Treatment in Reducing Risk of Developing Wound Healing, Obesity, Neurodegenerative Disorders, and Diabetes Mellitus
Mini-Reviews in Medicinal Chemistry N-type Calcium Channel Blockers: Novel Therapeutics for the Treatment of Pain
Medicinal Chemistry Physiological Roles of Neuronal Nicotinic Receptors Subtypes: New Insights on the Nicotinic Modulation of Neurotransmitter Release, Synaptic Transmission and Plasticity
Current Topics in Medicinal Chemistry Ca<sup>2+</sup>-Myristoyl Switch in Neuronal Calcium Sensor-1: A Role of C-Terminal Segment
CNS & Neurological Disorders - Drug Targets IP6 & Inositol in Cancer Prevention and Therapy
Current Cancer Therapy Reviews Implication for Thiazolidinediones (TZDs) as Novel Potential Anti- Inflammatory Drugs
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Editorial (Thematic Issue: Psychogeriatrics: An Interdisciplinary Approach)
Current Psychopharmacology