Antimicrobial Prenylated Xanthones and Anthraquinones from Barks and Fruits of Psorospermum adamauense (Engl)

Title:Antimicrobial Prenylated Xanthones and Anthraquinones from Barks and Fruits of Psorospermum adamauense (Engl)

Volume: 3 Issue: 1

Author(s): Tsaffack Maurice, Ouahouo Wache Blandine Marlyse, Nguemeving Jean Robert, Mkounga Pierre, Kuete Victor, Olov Sterner, Meyer Michelle and Nkengfack Augustin Ephrem

Affiliation:

Keywords: Adamaquinone, adamaxanthone, antimicrobial activity, hypericaceae, psorospermum, psorospermum adamauense

Abstract: One new prenylated xanthone derivative, named adamaxanthone (1) and one new prenylated anthraquinone derivative, adamaquinone (2) were isolated, respectively, from the methanol extract of the fruits and the stem bark of Psorospermum adamauense along with nine known compounds, including two xanthones [1,4,5,7-tetrahydroxyxanthone (3) and 1,2,3-trimethoxyxanthone (4)], two anthraquinones [2-isoprenylemodin (5) and (vismiaquinone (6)], one ferruginin [kengaquinone (7)], two anthrones [kenganthranol A (8) and 3-geranyloxyemodinanthrone (9)], one bianthrone [bianthrone A2b (10)], and one flavonoid [catechin (11)]. The structures of the new compounds were elucidated using spectroscopic methods and by comparison of their spectral data with those of the previously known analogues. The isolated compounds were evaluated for their antimicrobial activity against a wide range of drug-resistant pathogens and compound (3) was revealed to be the most active.

Cite this article as:

Maurice Tsaffack, Wache Blandine Marlyse Ouahouo, Jean Robert Nguemeving, Pierre Mkounga, Victor Kuete, Sterner Olov, Michelle Meyer and Augustin Ephrem Nkengfack, Antimicrobial Prenylated Xanthones and Anthraquinones from Barks and Fruits of Psorospermum adamauense (Engl), The Natural Products Journal 2013; 3 (1) . https://dx.doi.org/10.2174/2210315511303010011