Abstract
In continuation of our studies on the genus Salvia fourteen alcoholic extracts of Salvia species were evaluated for their anticholinesterase activity. Among them, the most active extract at 200 μg/mL was found to be S. staminea with the inhibition of 55.17 and 79.75% against enzymes AChE and BChE, respectively. Pure isolated compounds from S. staminea were investigated for anticholinesterase activity at 200 μM, and the abietane diterpenoids ferruginol and taxodione were found to be the most promising isolates, which were then further investigated at five different concentrations, and both diterpenoids exhibited high activity, particularly against BChE enzyme with IC50 values of 7.73 and 10.52 μM, respectively. Salvia chrysophylla and Salvia poculata extracts also exhibited moderate anticholinesterase activity.
Keywords: Anticholinesterase, antioxidant, ferruginol, Salvia species, S. staminea, taxodione
The Natural Products Journal
Title:Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea
Volume: 3 Issue: 1
Author(s): Gulactı Topcu, Ufuk Kolak, Mehmet Ozturk, Mehmet Boga, Seda Damla Hatipoglu, Fatemeh Bahadori, Burcu Culhaoglu and Tuncay Dirmenci
Affiliation:
Keywords: Anticholinesterase, antioxidant, ferruginol, Salvia species, S. staminea, taxodione
Abstract: In continuation of our studies on the genus Salvia fourteen alcoholic extracts of Salvia species were evaluated for their anticholinesterase activity. Among them, the most active extract at 200 μg/mL was found to be S. staminea with the inhibition of 55.17 and 79.75% against enzymes AChE and BChE, respectively. Pure isolated compounds from S. staminea were investigated for anticholinesterase activity at 200 μM, and the abietane diterpenoids ferruginol and taxodione were found to be the most promising isolates, which were then further investigated at five different concentrations, and both diterpenoids exhibited high activity, particularly against BChE enzyme with IC50 values of 7.73 and 10.52 μM, respectively. Salvia chrysophylla and Salvia poculata extracts also exhibited moderate anticholinesterase activity.
Export Options
About this article
Cite this article as:
Topcu Gulactı, Kolak Ufuk, Ozturk Mehmet, Boga Mehmet, Damla Hatipoglu Seda, Bahadori Fatemeh, Culhaoglu Burcu and Dirmenci Tuncay, Investigation of Anticholinesterase Activity of a Series of Salvia Extracts and the Constituents of Salvia staminea, The Natural Products Journal 2013; 3 (1) . https://dx.doi.org/10.2174/2210315511303010003
DOI https://dx.doi.org/10.2174/2210315511303010003 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Gene Therapy Approaches for Cardiovascular Diseases
Current Gene Therapy Modulation of Collagen Turnover in Cardiovascular Disease
Current Pharmaceutical Design Intracoronary Injection of Drugs to Treat No – Reflow Phenomenon and Microcirculatory Dysfunction
Cardiovascular & Hematological Agents in Medicinal Chemistry Calreticulin in the Heart: From Embryological Development to Cardiac Pathology.
Current Molecular Medicine High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects
Current Pharmaceutical Design Role of Sensory Neurons in Restitution and Healing of Gastric Ulcers
Current Pharmaceutical Design Neurosteroids and Sporadic Alzheimers Disease
Current Alzheimer Research Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets
Current Pharmaceutical Design Impact of Pulmonary Vascular Resistances in Heart Transplantation for Congenital Heart Disease
Current Cardiology Reviews Is there Evidence to Support the Use of Direct Factor Xa Inhibitors in Coronary Artery Disease?
Reviews on Recent Clinical Trials Cerebral Microbleeds Do Not Predict Hemorrhagic Transformation in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease
Current Neurovascular Research Early Growth Response-1 (EGR-1) – A Key player in Myocardial Cell Injury
Cardiovascular & Hematological Agents in Medicinal Chemistry The Effect of Sex and Gender on Diabetic Complications
Current Diabetes Reviews Attenuation of Microvascular Injury in Preconditioned Ischemic Myocardium: Imaging with Tc-99m Glucaric Acid and In-111 Human Fibrinogen
Current Molecular Imaging (Discontinued) DL-3-n-Butylphthalide, an Anti-Oxidant Agent, Prevents Neurological Deficits and Cerebral Injury Following Stroke per Functional Analysis, Magnetic Resonance Imaging and Histological Assessment
Current Neurovascular Research Subject Index To Volume 6
Endocrine, Metabolic & Immune Disorders - Drug Targets Pituitary Adenylate Cyclase Activating Polypeptide: A Potential Neuroprotective Peptide
Current Pharmaceutical Design Release of Adenosine and ATP During Ischemia and Epilepsy
Current Neuropharmacology N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP): Potential target molecule in research of heart, kidney and brain
Current Pharmaceutical Design