Abstract
Resolution of ternary and quaternary mixtures of paracetamol (PAR), desxtromethorphan (DEX), phenylephrine (PHE), and chlorpheniramine (CHL) was successfully achieved with minimum sample pre-treatment and without analyte separation using a rapid method based on partial least squares (PLS) and UV spectral data. Multivariate PLS calibration was performed using 35 ternary and quaternary mixtures and the model was employed for prediction of analyte in 15 external test samples. Simultaneous determination of the analytes was possible by analyzing absorbances between 210 and 300 nm. Q2 values which are a measure of the predictivity of the PLS models were between 0.9696 and 0.9880 in ternary mixtures and between 0.9230 and 0.9757 in quaternary mixtures. The PLS models were successfully applied to determine the analytes in real pharmaceutical preparations. The mean recoveries for the analytes in the real samples were between 95.25 and 102.4% in ternary and between 93.52 and 103.55% in quaternary mixtures.
Keywords: Chlorpheniramine, dextromethorphan, paracetamol, phenylephrine, partial least squares, pharmaceutical
Current Pharmaceutical Analysis
Title:Simultaneous Determination of Paracetamol, Dextromethorphan, Phenylephrine and Chlorpheniramine Using Partial Least Squares
Volume: 9 Issue: 2
Author(s): Masoud Shariati-Rad, Mohsen Irandoust, Niloufar Amin and Farhad Ahmadi
Affiliation:
Keywords: Chlorpheniramine, dextromethorphan, paracetamol, phenylephrine, partial least squares, pharmaceutical
Abstract: Resolution of ternary and quaternary mixtures of paracetamol (PAR), desxtromethorphan (DEX), phenylephrine (PHE), and chlorpheniramine (CHL) was successfully achieved with minimum sample pre-treatment and without analyte separation using a rapid method based on partial least squares (PLS) and UV spectral data. Multivariate PLS calibration was performed using 35 ternary and quaternary mixtures and the model was employed for prediction of analyte in 15 external test samples. Simultaneous determination of the analytes was possible by analyzing absorbances between 210 and 300 nm. Q2 values which are a measure of the predictivity of the PLS models were between 0.9696 and 0.9880 in ternary mixtures and between 0.9230 and 0.9757 in quaternary mixtures. The PLS models were successfully applied to determine the analytes in real pharmaceutical preparations. The mean recoveries for the analytes in the real samples were between 95.25 and 102.4% in ternary and between 93.52 and 103.55% in quaternary mixtures.
Export Options
About this article
Cite this article as:
Shariati-Rad Masoud, Irandoust Mohsen, Amin Niloufar and Ahmadi Farhad, Simultaneous Determination of Paracetamol, Dextromethorphan, Phenylephrine and Chlorpheniramine Using Partial Least Squares, Current Pharmaceutical Analysis 2013; 9 (2) . https://dx.doi.org/10.2174/1573412911309020009
DOI https://dx.doi.org/10.2174/1573412911309020009 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Memantine and Kynurenic Acid: Current Neuropharmacological Aspects
Current Neuropharmacology Tactile Angle Discrimination Decreases due to Subjective Cognitive Decline in Alzheimer’s Disease
Current Alzheimer Research Apolipoprotein A-I/HDL Infusion Therapy for Plaque Stabilization-Regression: A Novel Therapeutic Approach
Current Pharmaceutical Design Beyond the "Lock and Key" Paradigm: Targeting Lipid Rafts to Induce the Selective Apoptosis of Cancer Cells
Current Medicinal Chemistry Mitophagy and Disease: New Avenues for Pharmacological Intervention
Current Pharmaceutical Design Mastering the Treatment of Diabetes Mellitus Type 1 in Childhood and Adolescence
Current Pediatric Reviews Protection by Natural Honey Against Hyperhomocysteinemia in Rats
Vascular Disease Prevention (Discontinued) Adenosine and Sleep
Current Neuropharmacology Recent Advances in Nanotechnology: A Novel Therapeutic System for the Treatment of Alzheimer’s Disease
Current Drug Metabolism A Novel Dynamic Analysis of Mental Status Linked to Biogenic Amines and Psychopathology
Current Psychiatry Reviews Cytosine Methyltransferases as Tumor Markers
Current Genomics Modulation of Microglial Innate Immunity in Alzheimers Disease by Activation of Peroxisome Proliferator-activated Receptor Gamma
Current Medicinal Chemistry Innate Immune Surveillance in the Central Nervous System Following Legionella pneumophila Infection
CNS & Neurological Disorders - Drug Targets Protein-Protein Interaction (PPI) Network: Recent Advances in Drug Discovery
Current Drug Metabolism Psychiatric Polypharmacy, Etiology and Potential Consequences
Current Psychopharmacology Commentary: Anonymous Encounters: Alcoholics Anonymous, Al-Anon, and Overeaters Anonymous
Adolescent Psychiatry Contextualizing Genetics for Regional Heart Failure Care
Current Cardiology Reviews Emerging Therapies Targeting Tumor Vasculature in Multiple Myeloma and other Hematologic and Solid Malignancies
Current Cancer Drug Targets Animal Galectins and Plant Lectins as Tools for Studies in Neurosciences
Current Neuropharmacology Therapies for Hepatitis C Infection: Targeting the Non-Structural Proteins of HCV
Current Medicinal Chemistry - Anti-Infective Agents