Abstract
Small molecules with selective efficacy can be used as drugs. Drugs typically have a therapeutic dose range where the benefit from intended effects outweighs the cost of unintended (side) effects. Herein, I use case scenarios to illustrate potential advantages and pitfalls of treatment with drugs alone or in combination. Combinations of drugs may show surprising effects given the effects of individual drugs, in phenomena known as drug interactions. Drug interactions can be classified as synergistic or antagonistic, if the effect of the combination is higher or lower than expected, respectively. A better understanding of drug interactions and their relationship to phenotypes offers hope in finding drug combinations that have high therapeutic values.
Keywords: Antibiotic resistance, dose-response curves, drug combinations, drug interactions, drug synergy, pharmacology, selective efficacy, therapeutic window
Current Drug Discovery Technologies
Title:Drugs and their Interactions
Volume: 10 Issue: 2
Author(s): Murat Cokol
Affiliation:
Keywords: Antibiotic resistance, dose-response curves, drug combinations, drug interactions, drug synergy, pharmacology, selective efficacy, therapeutic window
Abstract: Small molecules with selective efficacy can be used as drugs. Drugs typically have a therapeutic dose range where the benefit from intended effects outweighs the cost of unintended (side) effects. Herein, I use case scenarios to illustrate potential advantages and pitfalls of treatment with drugs alone or in combination. Combinations of drugs may show surprising effects given the effects of individual drugs, in phenomena known as drug interactions. Drug interactions can be classified as synergistic or antagonistic, if the effect of the combination is higher or lower than expected, respectively. A better understanding of drug interactions and their relationship to phenotypes offers hope in finding drug combinations that have high therapeutic values.
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Cite this article as:
Cokol Murat, Drugs and their Interactions, Current Drug Discovery Technologies 2013; 10 (2) . https://dx.doi.org/10.2174/1570163811310020003
DOI https://dx.doi.org/10.2174/1570163811310020003 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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