Synthesis and QSAR Modeling of Novel Benzimidazolo Thiazolidinones, Thiazinones and 5-arylidene-2-imino Thiazolidinones as Antibacterial Agents

Title:Synthesis and QSAR Modeling of Novel Benzimidazolo Thiazolidinones, Thiazinones and 5-arylidene-2-imino Thiazolidinones as Antibacterial Agents

Volume: 9 Issue: 3

Author(s): Manjunath Ghate, Praveena Devi, Jignesh Parikh and Vivek K. Vyas

Affiliation:

Keywords: Antibacterial, Benzimidazole, QSAR, Thiazolidinone, Thiazinone, Iminothiazolidinone, 1H-NMR, QSAR, thiazolidin-4-one, schiff bases

Abstract: A novel series of benzimidazolo thiazolidinones, thiazinones and 5-arylidene-2-imino thiazolidinones were synthesized and evaluated for antibacterial activity. The compounds were synthesized in excellent yield and the structures were characterized on the basis of IR, 1H-NMR and MASS spectral data. Most of the synthesized compounds showed good antibacterial activity against Gram-positive and Gram-negative bacteria. QSAR study was carried out with synthesized compounds using molecular descriptors such as electronic, thermodynamic and steric. Molecular descriptors were used to derive QSAR models between antibacterial activity and structural properties. QSAR study suggested the need of a bulky group to enhance the antibacterial activity in these series of compounds.

Cite this article as:

Ghate Manjunath, Devi Praveena, Parikh Jignesh and K. Vyas Vivek, Synthesis and QSAR Modeling of Novel Benzimidazolo Thiazolidinones, Thiazinones and 5-arylidene-2-imino Thiazolidinones as Antibacterial Agents, Medicinal Chemistry 2013; 9 (3) . https://dx.doi.org/10.2174/1573406411309030017