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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

An Efficiently Sonochemical Synthesis of Novel Pyrazoles, Bipyrazoles and Pyrazol-3- ylPyrazolo[3,4-d]pyrimidines Incorporating 1H-benzoimidazole Moiety

Author(s): Nesreen S. Ahmed, Tamer S. Saleh and El-Sayed H. El-Mossalamy

Volume 17, Issue 2, 2013

Page: [194 - 202] Pages: 9

DOI: 10.2174/1385272811317020016

Price: $65

Abstract

Novel pyrazoles, bipyrazoles and pyrazol-3-ylpyrazolo[3,4-d]pyrimidines were synthesized using the versatil synthon 2-(1Hbenzimidazol- 2-yl)-3,3-bis(methylthio) acrylonitrile (1). Reactions were carried out under silent and ultrasonic conditions. In general, improvement in rates and yields were observed when reactions were carried out under ultrasonic irradiation compared with silent condition. Structures of the products were established on analytical and spectral data.

Keywords: Pyrazoles, Bipyrazoles, Benzimidazole, Ultrasonic irradiation, Pyrazolo[3, 4-d]pyrimidine


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