Abstract
New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The oximes exhibited anti- A. baumanii activity.
Some of the compounds exhibited good antibiofilm activity against the Gram-negative, non-fermentative bacilli P. aeruginosa and A. baumanii, and their possible target suggested by molecular modeling being the synthesis of the quorum sensing molecules employed by the Gram-negative microorganisms represented by N-acyl-l-homoserine lactones.Keywords: Dibenzothiepins, Anti-biofilm activity, Molecular modelling, A. baumanii
Current Organic Chemistry
Title:Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling
Volume: 17 Issue: 2
Author(s): Camelia Elena Stecoza, Magdalena Majekova, Pavol Majek, Miron Teodor Caproiu and Luminita Marutescu
Affiliation:
Keywords: Dibenzothiepins, Anti-biofilm activity, Molecular modelling, A. baumanii
Abstract: New dibenzo[b,e]thiepins were synthesized, characterized by elemental analysis, spectral studies (1H-NMR, 13C-NMR, IR) and screened for their microbicidal and antibiofilm properties. The new dibenzo[b,e]thiepins and their sulfones exhibited a broad spectrum of antimicrobial activity (superior for the S-oxidized compounds) being effective at low concentrations against a wide range of infectious microorganisms. The oximes exhibited anti- A. baumanii activity.
Some of the compounds exhibited good antibiofilm activity against the Gram-negative, non-fermentative bacilli P. aeruginosa and A. baumanii, and their possible target suggested by molecular modeling being the synthesis of the quorum sensing molecules employed by the Gram-negative microorganisms represented by N-acyl-l-homoserine lactones.Export Options
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Cite this article as:
Stecoza Elena Camelia, Majekova Magdalena, Majek Pavol, Caproiu Teodor Miron and Marutescu Luminita, Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020006
DOI https://dx.doi.org/10.2174/1385272811317020006 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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