Abstract
The first 24 hours of a preterm infant’s life is often a period of cardiovascular instability. A complex relationship exists between the heart, brain and systemic and cerebral vasculature and in the immediate neonatal period in which low blood pressure, low systemic blood flow and low cerebral blood flow are common. The preterm infant is at risk of low systemic blood flow (and low blood pressure) due to a combination of intrinsic factors (immaturity of the preterm myocardium and vasculature) as well as extrinsic factors (including mechanical ventilation and vasoactive medications). Low systemic blood flow is common in preterm infants and contributes significantly to the perinatal brain injury, which manifests as peri/intraventricular haemorrhage (P/IVH) and white matter injury. These in turn contribute to the significant neurological and/or developmental disabilities in survivors that impact long term on their quality of life. This paper will look at the evidence currently available for the management of low systemic blood flow in preterm infants.
Keywords: Preterm infant, systemic blood flow, cardiac output
Current Pediatric Reviews
Title:Strategies to Tackle Early Low Flow States in the Extremely Preterm Infant
Volume: 9 Issue: 1
Author(s): Mary Paradisis
Affiliation:
Keywords: Preterm infant, systemic blood flow, cardiac output
Abstract: The first 24 hours of a preterm infant’s life is often a period of cardiovascular instability. A complex relationship exists between the heart, brain and systemic and cerebral vasculature and in the immediate neonatal period in which low blood pressure, low systemic blood flow and low cerebral blood flow are common. The preterm infant is at risk of low systemic blood flow (and low blood pressure) due to a combination of intrinsic factors (immaturity of the preterm myocardium and vasculature) as well as extrinsic factors (including mechanical ventilation and vasoactive medications). Low systemic blood flow is common in preterm infants and contributes significantly to the perinatal brain injury, which manifests as peri/intraventricular haemorrhage (P/IVH) and white matter injury. These in turn contribute to the significant neurological and/or developmental disabilities in survivors that impact long term on their quality of life. This paper will look at the evidence currently available for the management of low systemic blood flow in preterm infants.
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Cite this article as:
Paradisis Mary, Strategies to Tackle Early Low Flow States in the Extremely Preterm Infant, Current Pediatric Reviews 2013; 9 (1) . https://dx.doi.org/10.2174/1573396311309010017
DOI https://dx.doi.org/10.2174/1573396311309010017 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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