Abstract
Sialic acids (Sia) play major roles in glycan-mediated recognition/interaction processes, which are mediated by various intrinsic and extrinsic sialic acid-binding proteins. Cells therefore require fine-tuned mechanisms to regulate cell-surface expression of sialoglycoconjugates. In mammalian cells, there are 4 distinct sialidases, termed NEU1, NEU2, NEU3 and NEU4, involved in the removal of sialic acid residues from glycoconjugates; they play pivotal roles in diverse biological processes. In this chapter we summarize our current knowledge on mammalian sialidases.
Keywords: Sialidases, neuraminidases, NEU1, NEU2, NEU3, NEU4, mammalian, sialic acid catabolism, 4-methylumbelliferyl neuraminic acid, sialidase subcellular localizations.
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