Meta Genome-wide Network from Functional Linkages of Genes in Human Gut Microbial Ecosystems

Title:Meta Genome-wide Network from Functional Linkages of Genes in Human Gut Microbial Ecosystems

Volume: 20 Issue: 3

Author(s): Yan ji, Yixiang Shi, Chuan Wang, Jianliang Dai and Yixue Li

Affiliation:

Keywords: Metagenome, network analysis, neighbor genes, microbes, meta-genomics, metabolic process, genome constitution, co-evolution properties, fingerprints, fermentation, glycans

Abstract: The human gut microbial ecosystem (HGME) exerts an important influence on the human health. In recent researches, meta-genomics provided deep insights into the HGME in terms of gene contents, metabolic processes and genome constitutions of meta-genome. Here we present a novel methodology to investigate the HGME on the basis of a set of functionally coupled genes regardless of their genome origins when considering the co-evolution properties of genes. By analyzing these coupled genes, we showed some basic properties of HGME significantly associated with each other, and further constructed a protein interaction map of human gut meta-genome to discover some functional modules that may relate with essential metabolic processes. Compared with other studies, our method provides a new idea to extract basic function elements from meta-genome systems and investigate complex microbial environment by associating its biological traits with co-evolutionary fingerprints encoded in it.

Cite this article as:

ji Yan, Shi Yixiang, Wang Chuan, Dai Jianliang and Li Yixue, Meta Genome-wide Network from Functional Linkages of Genes in Human Gut Microbial Ecosystems, Protein & Peptide Letters 2013; 20 (3) . https://dx.doi.org/10.2174/0929866511320030016