Advances in Organic Synthesis

Volume: 3

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...
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Biocatalysis in the Preparation of the Statin Side Chain

Pp. 195-236 (42)

DOI: 10.2174/9781608054688113030008

Author(s): Arto Liljeblad, Annukka Kallinen, Liisa T. Kanerva


Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.


Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nirilase, aldolase.