Biocatalysis in the Preparation of the Statin Side Chain

Advances in Organic Synthesis

Volume: 3

DOI: 10.2174/9781608054688113030008
eISBN: 978-1-60805-468-8, 2013
ISBN: 978-1-60805-587-6
ISSN: 1574-0870 (Print)

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...

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Biocatalysis in the Preparation of the Statin Side Chain

Pp. 195-236 (42)

Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva

Abstract

Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

Keywords:

Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nirilase, aldolase.

Affiliation:

Pharmacology, Drug Development and Therapeutics, Laboratory of Synthetic Drug Chemistry and Department of Chemistry, University of Turku, Lemminkäisenkatu 5 C, FIN-20520, Turku, Finland