Abstract
In recent years, targeted ultrasound contrast agents (UCA) have emerged with the rapid development of contrast-enhanced ultrasound technology and bio-nanotechnology, showing good prospects for applications in molecular imaging and targeted therapy. The non-invasive treatment modality can reduce the drug dosage, toxicity and side effects, providing a new kind of methodology and approach for treatments, which will greatly expand the research and its applications. Targeted UCA have been developed rapidly in recent years, and a variety of new UCA appear, such as multi-functional UCA, multi-modal UCA, UCA with double ligands or more ligands, long-circulating UCA and immune type UCA, which meet growing clinical and research needs. The novel UCA have made a great progress and play an increasingly important role in molecular imaging. In this article, we reviewed the concepts of ultrasound molecular imaging, and summarized the applications of targeted UCA in molecular imaging and targeted therapy.
Keywords: Contrast agent, microbubble, targeted, molecular imaging, diagnosis, therapy, ultrasound contrast agents (UCA), drug dosage
Current Pharmaceutical Design
Title:Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Volume: 19 Issue: 8
Author(s): Feng Yang, Zhi-Yi Chen and Yan Lin
Affiliation:
Keywords: Contrast agent, microbubble, targeted, molecular imaging, diagnosis, therapy, ultrasound contrast agents (UCA), drug dosage
Abstract: In recent years, targeted ultrasound contrast agents (UCA) have emerged with the rapid development of contrast-enhanced ultrasound technology and bio-nanotechnology, showing good prospects for applications in molecular imaging and targeted therapy. The non-invasive treatment modality can reduce the drug dosage, toxicity and side effects, providing a new kind of methodology and approach for treatments, which will greatly expand the research and its applications. Targeted UCA have been developed rapidly in recent years, and a variety of new UCA appear, such as multi-functional UCA, multi-modal UCA, UCA with double ligands or more ligands, long-circulating UCA and immune type UCA, which meet growing clinical and research needs. The novel UCA have made a great progress and play an increasingly important role in molecular imaging. In this article, we reviewed the concepts of ultrasound molecular imaging, and summarized the applications of targeted UCA in molecular imaging and targeted therapy.
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Cite this article as:
Yang Feng, Chen Zhi-Yi and Lin Yan, Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy, Current Pharmaceutical Design 2013; 19 (8) . https://dx.doi.org/10.2174/1381612811319080019
DOI https://dx.doi.org/10.2174/1381612811319080019 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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