Abstract
Cervical cancer is a major health problem and almost all of these cancers are related to a high risk Human Papillomavirus cervical infection.
The Human Papillomavirus transforming potential has long been probed and is mainly characterized by the integration of the virus in the host genomes and the expression of the viral oncoproteins such as the E6 and E7 mRNAs. The vast majority of the HPV infections are transient and resolve and just a few percentages of patients are noted to develop a persistent infection. Therefore, there is the need of identifying appropriate biomarkers that can predict and differentiate transient vs persistent and clinical relevant HPV cervical infections.
To date, two categories of commercial assays have been introduced, mainly aiming to the detection of the E6 and E7 mRNAs and of the surrogates of the E7 activity (p16ink4A protein).
The aim of the present study is to analyse the basis of the HPV-related carcinogenesis and to discuss the commercial biomarkers developed to-date, reviewing those studies that used the above-mentioned assays in a clinical setting.
Keywords: HPV, E6, E7, p16, molecular test, cervical cancer, viral oncoproteins, mRNAs, p16ink4A protein, biomarkers
Current Pharmaceutical Design
Title:HPV Infections: Basis of Neoplastic Transformation and Related Molecular Tests
Volume: 19 Issue: 8
Author(s): Deborah French and Laura Lorenzon
Affiliation:
Keywords: HPV, E6, E7, p16, molecular test, cervical cancer, viral oncoproteins, mRNAs, p16ink4A protein, biomarkers
Abstract: Cervical cancer is a major health problem and almost all of these cancers are related to a high risk Human Papillomavirus cervical infection.
The Human Papillomavirus transforming potential has long been probed and is mainly characterized by the integration of the virus in the host genomes and the expression of the viral oncoproteins such as the E6 and E7 mRNAs. The vast majority of the HPV infections are transient and resolve and just a few percentages of patients are noted to develop a persistent infection. Therefore, there is the need of identifying appropriate biomarkers that can predict and differentiate transient vs persistent and clinical relevant HPV cervical infections.
To date, two categories of commercial assays have been introduced, mainly aiming to the detection of the E6 and E7 mRNAs and of the surrogates of the E7 activity (p16ink4A protein).
The aim of the present study is to analyse the basis of the HPV-related carcinogenesis and to discuss the commercial biomarkers developed to-date, reviewing those studies that used the above-mentioned assays in a clinical setting.
Export Options
About this article
Cite this article as:
French Deborah and Lorenzon Laura, HPV Infections: Basis of Neoplastic Transformation and Related Molecular Tests, Current Pharmaceutical Design 2013; 19 (8) . https://dx.doi.org/10.2174/1381612811319080003
DOI https://dx.doi.org/10.2174/1381612811319080003 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cancer-Associated Carbonic Anhydrases and Their Inhibition
Current Pharmaceutical Design Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review
Current Pharmaceutical Design Metallopharmaceuticals in Therapy - A New Horizon for Scientific Research
Current Medicinal Chemistry Drug Metabolism and Transport Under Hypoxia
Current Drug Metabolism Flavonoids: Recent Advances as Anticancer Drugs
Recent Patents on Anti-Cancer Drug Discovery Probing Gallic Acid for Its Broad Spectrum Applications
Mini-Reviews in Medicinal Chemistry Engineering Nanomedicines to Overcome Multidrug Resistance in Cancer Therapy
Current Medicinal Chemistry Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design Alpha-1 Antitrypsin: It’s Role in Health and Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Views of Young Women on HPV Vaccine Communication in Four European Countries
Current HIV Research 4-Anilinoquinazoline Derivatives with Epidermal Growth Factor Receptor Inhibitor Activity
Anti-Cancer Agents in Medicinal Chemistry Nicotine Vaccines
CNS & Neurological Disorders - Drug Targets Juglone Exerts Cytotoxic, Anti-proliferative and Anti-invasive Effects on Glioblastoma Multiforme in a Cell Culture Model
Anti-Cancer Agents in Medicinal Chemistry Proteomic and Metallomic Strategies for Understanding the Mode of Action of Anticancer Metallodrugs
Anti-Cancer Agents in Medicinal Chemistry Clinical Use of Therapies Targeting Tumor Vasculature and Stroma
Current Cancer Drug Targets Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents
Anti-Cancer Agents in Medicinal Chemistry Heterogeneity Amongst 5-HT3 Receptor Subunits: Is this Significant?
Current Molecular Medicine Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer
Current Medicinal Chemistry Rational Combination of Targeted Therapies As A Strategy to Overcome The Mechanisms of Resistance to Inhibitors of EGFR Signaling
Current Pharmaceutical Design Investigating the In Vivo Expression Patterns of miR-7 microRNA Family Members in the Adult Mouse Brain
MicroRNA