Human Stem Cells and Articular Cartilage Tissue Engineering

J-F.      Stoltz; C.      Huselstein; J.      Schiavi; Y.Y.      Li; D.      Bensoussan; V.      Decot; N.      De Isla

Abstract

Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. Despite progress in orthopaedic surgery, cell-based surgical therapies such as autologous chondrocyte transplantation (ACT) have been in clinical use for cartilage repair for over a decade but this approach has shown mixed results. Moreover, the lack of efficient modalities of treatment for large chondral defects has prompted research on cartilage tissue engineering combining cells, scaffold materials and environmental factors. This paper focuses on the main parameters in tissue engineering and in particular, on the potential of mesenchymal stem cells (MSCs) as an alternative to cells derived from patient tissues in autologous transplantation and tissue engineering. We discussed the prospects of using autologous chondrocytes or MSCs in regenerative medicine and summarized the advantages and disadvantages of these cells in articular cartilage engineering.

Keywords: Articular Cartilage, Bioengineering, Regenerative medicine, Scaffolds, Mesenchymal Stem cells, cartilage tissue, autologous chondrocyte transplantation (ACT), orthopaedic surgery, surgical therapies