Abstract
Glycosphingolipids (GSLs) are present in all mammalian cell plasma membranes and intracellular membrane structures. They are especially concentrated in plasma membrane lipid domains that are specialized for cell signaling. Plasma membranes show typical structures called rafts and caveola domain structures, with large amounts of sphingolipids, cholesterol, and sphingomyelin in the cell membranes. Plasma membranes have two faces, many kinds of receptors for intercellular signal transducers such as GPI-anchored proteins on the exoplasmic faces of the rafts/caveolae and src family kinases on the cytosolic face. Thus they play a role in transmembrane signal transduction, following the phosphorylation of some substrates and gene expression. On the other hand, their functions have become clear through the study of gene-manipulated mice. For further advances, a visual method to display diversity of biological functions is necessary. For this purpose, the use of high-performance microscopes and live cell imaging technologies are useful for more detailed understanding.
Keywords: Glycosphingolipids, embryonic lethality, development, neuronal function, mammalian cell plasma, cell signaling, phingolipids, sphingomyelin, GPI-anchored proteins, gene expression, gene-manipulated mice, biological functions, eukaryotic cells, nervous system
Current Pharmaceutical Biotechnology
Title:Recent Advances in the Study of Glycosphingolipids
Volume: 13 Issue: 14
Author(s): Tadashi Yamashita
Affiliation:
Keywords: Glycosphingolipids, embryonic lethality, development, neuronal function, mammalian cell plasma, cell signaling, phingolipids, sphingomyelin, GPI-anchored proteins, gene expression, gene-manipulated mice, biological functions, eukaryotic cells, nervous system
Abstract: Glycosphingolipids (GSLs) are present in all mammalian cell plasma membranes and intracellular membrane structures. They are especially concentrated in plasma membrane lipid domains that are specialized for cell signaling. Plasma membranes show typical structures called rafts and caveola domain structures, with large amounts of sphingolipids, cholesterol, and sphingomyelin in the cell membranes. Plasma membranes have two faces, many kinds of receptors for intercellular signal transducers such as GPI-anchored proteins on the exoplasmic faces of the rafts/caveolae and src family kinases on the cytosolic face. Thus they play a role in transmembrane signal transduction, following the phosphorylation of some substrates and gene expression. On the other hand, their functions have become clear through the study of gene-manipulated mice. For further advances, a visual method to display diversity of biological functions is necessary. For this purpose, the use of high-performance microscopes and live cell imaging technologies are useful for more detailed understanding.
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Cite this article as:
Yamashita Tadashi, Recent Advances in the Study of Glycosphingolipids, Current Pharmaceutical Biotechnology 2012; 13 (14) . https://dx.doi.org/10.2174/138920101314151120122928
DOI https://dx.doi.org/10.2174/138920101314151120122928 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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