Abstract
Vinorelbine tartrate is a semi-synthetic drug with a broad-spectrum anti-tumor activity. An injectable formulation of vinorelbine (Navelbine® IV) has been widely used in the world, despite existing some disadvantages. In this study, in order to improve the efficacy of vinorelbine injection metabolism with minimal side effects, rHSA nanoparticles entrapping VLBT were prepared by a desolvation procedure, and subsequently decorated by folic acid. A central composite design was applied for modeling the process. To some extent, the drug release rate could be adjusted by cross-linking with different amount of glutaraldehyde. In this paper, FarHSANPs- VLBT with three degrees (25%, 50% and 75%) of cross-linking were obtained under the optimum conditions for preparing the nanoparticles. Then we carried out a further study to compare the characteristics of the nanoparticles, such as drug entrapment efficiency (DEE), drug-loading efficiency (DLE), surface morphology, surface chemistry, physical status of VLBT in Fa-rHSANPs-VLBT, amount of folate conjugation, and release kinetics in vitro. The experiment results displayed that as the degree of cross-linking increased, both the zeta potential (ZP) and folate content associated with the VLBT-rHSANPs showing a reduced tend. Moreover, the increasing glutaraldehyde concentration made the rate of release of the VLBT from these nanoparticles decrease.
Keywords: Controlled release, different degree of cross-linkingbine, physicochemical properties, particle sizing, recombination human serum albumin, response surface methodology, vinorelbine tartrate
Current Nanoscience
Title:Preparation, Characterization, and In Vitro Release of Vinorelbine Tartrate (VLBT)- Loaded Folate-conjugated Recombination Human Serum Albumin (rHSA) Nanoparticles with Different Degree of Cross-linking
Volume: 8 Issue: 6
Author(s): Yuangang Zu, Xue Han, Xiuhua Zhao, Yong Li, Wei Wang and Chengbo Gu
Affiliation:
Keywords: Controlled release, different degree of cross-linkingbine, physicochemical properties, particle sizing, recombination human serum albumin, response surface methodology, vinorelbine tartrate
Abstract: Vinorelbine tartrate is a semi-synthetic drug with a broad-spectrum anti-tumor activity. An injectable formulation of vinorelbine (Navelbine® IV) has been widely used in the world, despite existing some disadvantages. In this study, in order to improve the efficacy of vinorelbine injection metabolism with minimal side effects, rHSA nanoparticles entrapping VLBT were prepared by a desolvation procedure, and subsequently decorated by folic acid. A central composite design was applied for modeling the process. To some extent, the drug release rate could be adjusted by cross-linking with different amount of glutaraldehyde. In this paper, FarHSANPs- VLBT with three degrees (25%, 50% and 75%) of cross-linking were obtained under the optimum conditions for preparing the nanoparticles. Then we carried out a further study to compare the characteristics of the nanoparticles, such as drug entrapment efficiency (DEE), drug-loading efficiency (DLE), surface morphology, surface chemistry, physical status of VLBT in Fa-rHSANPs-VLBT, amount of folate conjugation, and release kinetics in vitro. The experiment results displayed that as the degree of cross-linking increased, both the zeta potential (ZP) and folate content associated with the VLBT-rHSANPs showing a reduced tend. Moreover, the increasing glutaraldehyde concentration made the rate of release of the VLBT from these nanoparticles decrease.
Export Options
About this article
Cite this article as:
Zu Yuangang, Han Xue, Zhao Xiuhua, Li Yong, Wang Wei and Gu Chengbo, Preparation, Characterization, and In Vitro Release of Vinorelbine Tartrate (VLBT)- Loaded Folate-conjugated Recombination Human Serum Albumin (rHSA) Nanoparticles with Different Degree of Cross-linking, Current Nanoscience 2012; 8 (6) . https://dx.doi.org/10.2174/157341312803989042
DOI https://dx.doi.org/10.2174/157341312803989042 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oncomirs: From Tumor Biology to Molecularly Targeted Anticancer Strategies
Mini-Reviews in Medicinal Chemistry A Neuroinformatics Study Describing Molecular Interaction of Cisplatin with Acetylcholinesterase: A Plausible Cause for Anticancer Drug Induced Neurotoxicity
CNS & Neurological Disorders - Drug Targets Epigenetic Interventions Increase the Radiation Sensitivity of Cancer Cells
Current Pharmaceutical Design Current Biomarkers for Lung Cancer
Current Signal Transduction Therapy Morpho-Functional Features of In-Vitro Cell Death Induced by Physical Agents
Current Pharmaceutical Design Pharmacological Roles of the Large-Conductance Calcium-Activated Potassium Channel
Current Topics in Medicinal Chemistry Recent Advances in the Molecular Pathogenesis of Dystonia-Plus Syndromes and Heredodegenerative Dystonias
Current Neuropharmacology Substance P and Alzheimer’s Disease: Emerging Novel Roles
Current Alzheimer Research The Endocannabinoid System in Amyotrophic Lateral Sclerosis
Current Pharmaceutical Design Cordycepin Suppresses Integrin/FAK Signaling and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
Anti-Cancer Agents in Medicinal Chemistry Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C
Current Molecular Pharmacology Aflibercept: A Novel VEGF Targeted Agent to Explore the Future Perspectives of Anti-Angiogenic Therapy for the Treatment of Multiple Tumors
Mini-Reviews in Medicinal Chemistry Targeting Tumors with Small Molecule Peptides
Current Cancer Drug Targets Vascular Endothelial Growth Factor Receptors [VEGFR] as Target in Breast Cancer Treatment: Current Status in Preclinical and Clinical Studies and Future Directions
Current Topics in Medicinal Chemistry Functional Role of Glycosphingolipids in Cancer
Current Medicinal Chemistry Some Implications of Receptor Kinase Signaling Pathway for Development of Multitargeted Kinase Inhibitors
Current Radiopharmaceuticals Small Molecule Antagonists of the Corticotropin Releasing Factor (CRF)Receptor: Recent Medicinal Chemistry Developments
Current Topics in Medicinal Chemistry Complement and Microglia in the Neuropathogenesis of HIV Infection: Pro- and Anti-Inflammatory Aspects
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Nature Against Depression
Current Medicinal Chemistry Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?
Current Medicinal Chemistry