Abstract
Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.
Keywords: Cascade reaction, multicomponent reaction, one-pot synthesis, tandem reaction, telescoping.
Current Organic Synthesis
Title:One-pot Synthesis and its Practical Application in Pharmaceutical Industry
Volume: 9 Issue: 6
Author(s): Wenyi Zhao and Fen-Er Chen
Affiliation:
Keywords: Cascade reaction, multicomponent reaction, one-pot synthesis, tandem reaction, telescoping.
Abstract: Compared with conventional batch-wise process, one-pot synthesis is the “condensation” of two or more steps into one-pot operation and increasingly used in chemical process research and development in order to achieve the desired molecular complexity in ecologically and economically efficient way. One-pot synthesis can be achieved via multicomponent reaction (MCR), cascade reaction, tandem reaction, or telescoping synthetic steps. This review summarizes recent progresses in this field, covering mainly four approaches developed for the application towards one-pot organic synthesis.
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Cite this article as:
Zhao Wenyi and Chen Fen-Er, One-pot Synthesis and its Practical Application in Pharmaceutical Industry, Current Organic Synthesis 2012; 9 (6) . https://dx.doi.org/10.2174/157017912803901619
DOI https://dx.doi.org/10.2174/157017912803901619 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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