Abstract
Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca2+ release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies. These discoveries have led to the development of novel drugs, screening tools, and research methods. The patents associated with these advances tell the story of the initial discovery of RyRs as a target for plant alkaloids, to their central role in cardiac and skeletal muscle excitation-contraction coupling, and ongoing clinical trials with a novel class of drugs called RycalsTM that inhibit pathological intracellular Ca2+ leak. Additionally, these patents highlight questions, controversies, and future directions of the RyR field.
Keywords: Ryanodine, calcium, EC-coupling, myocardium, skeletal muscle, sarcoplasmic reticulum (SR), calcium leakage, leaky SR, Rycal, JTV519, S107, heart failure, malignant hyperthermia, arrhythmias, patents
Recent Patents on Biotechnology
Title:Ryanodine Receptor Patents
Volume: 6 Issue: 3
Author(s): Alexander Kushnir and Andrew R. Marks
Affiliation:
Keywords: Ryanodine, calcium, EC-coupling, myocardium, skeletal muscle, sarcoplasmic reticulum (SR), calcium leakage, leaky SR, Rycal, JTV519, S107, heart failure, malignant hyperthermia, arrhythmias, patents
Abstract: Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca2+ release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies. These discoveries have led to the development of novel drugs, screening tools, and research methods. The patents associated with these advances tell the story of the initial discovery of RyRs as a target for plant alkaloids, to their central role in cardiac and skeletal muscle excitation-contraction coupling, and ongoing clinical trials with a novel class of drugs called RycalsTM that inhibit pathological intracellular Ca2+ leak. Additionally, these patents highlight questions, controversies, and future directions of the RyR field.
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Cite this article as:
Kushnir Alexander and R. Marks Andrew, Ryanodine Receptor Patents, Recent Patents on Biotechnology 2012; 6 (3) . https://dx.doi.org/10.2174/1872208311206030157
DOI https://dx.doi.org/10.2174/1872208311206030157 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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