Abstract
Allergic diseases are major diseases involving approximately 22% of world population. In recent years, accumulated evidence suggests that apart from IgE, allergens may provoke immediate allergic reactions via other pathways such as IgG, toll like receptor (TLR) dependent ones. In addition, large numbers of low molecular weight molecules (LMWM) such as sphingosine-1-phosphate and iodinated contrast agents have been observed to cause allergy. Therefore, the current definition of allergy, a group of IgE mediated diseases appears difficult to cover all allergic reactions. Since even IgE dependent allergic reactions are carried out through activation of mast cells and basophils, and all allergens mentioned above can activate these cells, we hypothesize that allergic reactions are mast cell and basophil mediated inflammatory process as it is the activated mast cells and basophils that initiate the pathological process of the immediate allergic reactions, whereas IgE only serves as one of the activators of these cells.
Keywords: Allergen, cytokine, degranulation, effector cells, IgG, self-amplification, rhinitis, asthma, dermatitis, conjunctivitis, anaphylaxis, inflammation, allergy, immune system, antigen
Current Molecular Medicine
Title:Self-Amplification Mechanisms of Mast Cell Activation: A New Look in Allergy
Volume: 12 Issue: 10
Author(s): S. He, H. Zhang, X. Zeng and P. Yang
Affiliation:
Keywords: Allergen, cytokine, degranulation, effector cells, IgG, self-amplification, rhinitis, asthma, dermatitis, conjunctivitis, anaphylaxis, inflammation, allergy, immune system, antigen
Abstract: Allergic diseases are major diseases involving approximately 22% of world population. In recent years, accumulated evidence suggests that apart from IgE, allergens may provoke immediate allergic reactions via other pathways such as IgG, toll like receptor (TLR) dependent ones. In addition, large numbers of low molecular weight molecules (LMWM) such as sphingosine-1-phosphate and iodinated contrast agents have been observed to cause allergy. Therefore, the current definition of allergy, a group of IgE mediated diseases appears difficult to cover all allergic reactions. Since even IgE dependent allergic reactions are carried out through activation of mast cells and basophils, and all allergens mentioned above can activate these cells, we hypothesize that allergic reactions are mast cell and basophil mediated inflammatory process as it is the activated mast cells and basophils that initiate the pathological process of the immediate allergic reactions, whereas IgE only serves as one of the activators of these cells.
Export Options
About this article
Cite this article as:
He S., Zhang H., Zeng X. and Yang P., Self-Amplification Mechanisms of Mast Cell Activation: A New Look in Allergy, Current Molecular Medicine 2012; 12 (10) . https://dx.doi.org/10.2174/156652412803833544
DOI https://dx.doi.org/10.2174/156652412803833544 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Alteration of Cholinergic System in Keratinocytes Cells Produces Acantholysis: A Possible Use of Cholinergic Drugs in Pemphigus Vulgaris
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Current Concepts on Cardiovascular Stent Devices
Mini-Reviews in Medicinal Chemistry Gene Delivery for Cancer Therapy
Current Drug Delivery Structure-Activity Relationships of Low Molecular Weight Heparins Expose to the Risk of Achieving Inappropriate Targets in Patients with Renal Failure
Current Medicinal Chemistry Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy
Endocrine, Metabolic & Immune Disorders - Drug Targets The Relationship Between Diabetes Mellitus, Geriatric Syndromes, Physical Function, and Gait: A Review of the Literature
Current Diabetes Reviews Gene Therapy and Targeted Toxins for Glioma
Current Gene Therapy Autoantibodies in Autoimmune Diseases
Current Pharmaceutical Design High Doses of In vitro Beta-carotene, Alpha-Tocopherol and Ascorbic Acid Induce Oxidative Stress and Secretion of IL-6 in Peripheral Blood Mononuclear Cells from Healthy Donors
Current Aging Science Endothelial Dysfunction Induced by Cadmium and Mercury and its Relationship to Hypertension
Current Hypertension Reviews Identification of Potential Drug Therapy for Dermatofibrosarcoma Protuberans with Bioinformatics and Deep Learning Technology
Current Computer-Aided Drug Design Strategies to Create a Regenerating Environment for the Injured Spinal Cord
Current Pharmaceutical Design Probiotics for Gastrointestinal and Liver Diseases: An Updated Review of the Published Literature
Endocrine, Metabolic & Immune Disorders - Drug Targets Glutamatergic Animal Models of Schizophrenia
Current Pharmaceutical Design Modulation of 3,4-Methylenedioxymethamphetamine Effects by Endocannabinoid System
Current Pharmaceutical Design Dendritic Cell-Based Immune Therapy in Liver Diseases
Current Immunology Reviews (Discontinued) Functional PLGA NPs for Oral Drug Delivery: Recent Strategies and Developments
Mini-Reviews in Medicinal Chemistry Assessment of Effect of Intra-pocket Delivery of Metronidazole Loaded NTrimethyl Quaternary Ammonium Chitosan Nanoparticles in Treatment of Periodontal Disease
Current Drug Therapy Vitamin D Analogs as Anti-Carcinogenic Agents
Anti-Cancer Agents in Medicinal Chemistry Control of Interleukin-1β Secretion in Inflammation and Immune Response
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents