Abstract
Cellular repressor of E1A-stimulated genes (CREG), a novel cellular protein, was discovered in 1998. Accumulating evidence, mainly from our laboratory, has suggested that CREG plays critical roles in reducing neointimal hyperplasia, maintaining vascular homeostasis, and promoting endothelial restoration. The study of CREG has the potential to offer new insights into both prevention and treatment of proliferative vascular disease, and will help us understand the processes of vascular repair after injury. It will also contribute to the development of new therapeutic strategies and devices, such as anti-in-stent restenosis stents. The present review summarizes our research on the molecular identity of CREG, and reviews the biological activities of CREG in regulating cell differentiation, proliferation, migration, and apoptosis of vascular smooth muscle cells and endothelial cells.
Keywords: Atherosclerosis, CREG, EC, restenosis, VSMC, heart disease, myocardial infarction, ischemic heart failure, inflammatory disease, vascular endothelial injury, platelet adherence, atherosclerotic plaque, myocardial revascularization, coronary stents, hyperplasia
Current Molecular Medicine
Title:CREG: A Possible Candidate for Both Prevention and Treatment of Proliferative Vascular Disease
Volume: 12 Issue: 10
Author(s): Y. Li, C.-H. Yan, S.-H. Li and Y.-L. Han
Affiliation:
Keywords: Atherosclerosis, CREG, EC, restenosis, VSMC, heart disease, myocardial infarction, ischemic heart failure, inflammatory disease, vascular endothelial injury, platelet adherence, atherosclerotic plaque, myocardial revascularization, coronary stents, hyperplasia
Abstract: Cellular repressor of E1A-stimulated genes (CREG), a novel cellular protein, was discovered in 1998. Accumulating evidence, mainly from our laboratory, has suggested that CREG plays critical roles in reducing neointimal hyperplasia, maintaining vascular homeostasis, and promoting endothelial restoration. The study of CREG has the potential to offer new insights into both prevention and treatment of proliferative vascular disease, and will help us understand the processes of vascular repair after injury. It will also contribute to the development of new therapeutic strategies and devices, such as anti-in-stent restenosis stents. The present review summarizes our research on the molecular identity of CREG, and reviews the biological activities of CREG in regulating cell differentiation, proliferation, migration, and apoptosis of vascular smooth muscle cells and endothelial cells.
Export Options
About this article
Cite this article as:
Li Y., Yan C.-H., Li S.-H. and Han Y.-L., CREG: A Possible Candidate for Both Prevention and Treatment of Proliferative Vascular Disease, Current Molecular Medicine 2012; 12 (10) . https://dx.doi.org/10.2174/156652412803833526
DOI https://dx.doi.org/10.2174/156652412803833526 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Taking Risk Prediction to the Next Level. Advances in Biomarker Research for Atherosclerosis
Current Pharmaceutical Design Marine Collagen as a Source of Bioactive Molecules: A Review
The Natural Products Journal Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases
Current Pharmaceutical Design Link between Metabolic Syndrome and Insulin Resistance
Current Vascular Pharmacology Effects of ACE-Inhibitors and Angiotensin Receptor Blockers on Inflammation
Current Pharmaceutical Design Matrix Metalloproteinases as Valid Clinical Target
Current Pharmaceutical Design Cardiovascular Disease in Systemic Lupus Erythematosus: The Role of Traditional and Lupus Related Risk Factors
Current Cardiology Reviews Chromones and their Derivatives as Radical Scavengers: A Remedy for Cell Impairment
Current Topics in Medicinal Chemistry An Introduction to the Nutrition and Metabolism of Choline
Central Nervous System Agents in Medicinal Chemistry Personalized and Participatory Medicine as a Future Tool to Combat Cardiovascular Disease in Developing Countries
Current Pharmacogenomics and Personalized Medicine In Vitro Blood-Brain Barrier Models – Latest Advances and Therapeutic Applications in a Chronological Perspective
Mini-Reviews in Medicinal Chemistry Regulation and Function of Rankl in Arterial Calcification
Current Pharmaceutical Design A synopsis on the linkage between age-related dementias and vascular disorders
CNS & Neurological Disorders - Drug Targets Development of Physical Disability in Older Adults
Current Aging Science Inverse Regulation of MMP-9 and MMP-2 in Long-Term Follow-up After Acute Coronary Syndrome: Lack of Correlation with Platelet and Endothelial Cell Activation Markers
Vascular Disease Prevention (Discontinued) Hormone Replacement Therapy and Stroke
Current Vascular Pharmacology Pharmacogenomic Considerations of the Insertion / Deletion Gene Polymorphism of the Angiotensin I-Converting Enzyme and Coronary Artery Disease
Current Vascular Pharmacology The Molecular Concept of Atheromatous Plaques
Current Drug Targets Recent Advances in Biological Strategies for Targeted Drug Delivery
Cardiovascular & Hematological Disorders-Drug Targets Glucose Tolerance Status in Pregnancy: A Window to the Future Risk of Diabetes and Cardiovascular Disease in Young Women
Current Diabetes Reviews