Abstract
Objective: To investigate nephroprotective potential of Urtica parviflora (UP) against paracetamol (PCM) induced nephrotoxicity in rats.
Methods: Nephrotoxicity was induced in rats by chronic administration of PCM (1 g/kg body weight p.o.) for 21 days. Different doses of UP (250, 500 and 750 mg/kg b.w., p.o.) were administered for 21 days along with PCM. Blood urea, blood urea nitrogen (BUN), serum creatinine, total protein, serum and tissue nitrite, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated. The effect of extract treatment on the renal histopathological profile in PCM nephrotoxic rats was also evaluated.
Results: PCM treatment significantly elevated blood urea, BUN, creatinine, serum nitrite and renal lipid peroxidation along with significant decrement in renal enzymatic and non-enzymatic antioxidants, total proteins while UP treatment significantly attenuated these alterations. The extract was also effective in mitigating renal histopathological changes induced by PCM.
Conclusions: The results suggested potent nephroprotective and antioxidant properties of Urtica parviflora.
Keywords: Urtica parviflora, paracetamol, nephrotoxicity, antioxidant activity, enzymatic, non-enzymatic, lipid, serum, protien, antioxidant.
The Natural Products Journal
Title:Nephroprotective Potential of Urtica parviflora Roxb. Against Paracetamol Induced Nephrotoxicity in Rats
Volume: 2 Issue: 4
Author(s): Savita Pandey, Sangeeta P. Sah and Anita Singh
Affiliation:
Keywords: Urtica parviflora, paracetamol, nephrotoxicity, antioxidant activity, enzymatic, non-enzymatic, lipid, serum, protien, antioxidant.
Abstract: Objective: To investigate nephroprotective potential of Urtica parviflora (UP) against paracetamol (PCM) induced nephrotoxicity in rats.
Methods: Nephrotoxicity was induced in rats by chronic administration of PCM (1 g/kg body weight p.o.) for 21 days. Different doses of UP (250, 500 and 750 mg/kg b.w., p.o.) were administered for 21 days along with PCM. Blood urea, blood urea nitrogen (BUN), serum creatinine, total protein, serum and tissue nitrite, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated. The effect of extract treatment on the renal histopathological profile in PCM nephrotoxic rats was also evaluated.
Results: PCM treatment significantly elevated blood urea, BUN, creatinine, serum nitrite and renal lipid peroxidation along with significant decrement in renal enzymatic and non-enzymatic antioxidants, total proteins while UP treatment significantly attenuated these alterations. The extract was also effective in mitigating renal histopathological changes induced by PCM.
Conclusions: The results suggested potent nephroprotective and antioxidant properties of Urtica parviflora.
Export Options
About this article
Cite this article as:
Pandey Savita, P. Sah Sangeeta and Singh Anita, Nephroprotective Potential of Urtica parviflora Roxb. Against Paracetamol Induced Nephrotoxicity in Rats, The Natural Products Journal 2012; 2 (4) . https://dx.doi.org/10.2174/2210315511202040316
DOI https://dx.doi.org/10.2174/2210315511202040316 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Overdoses of Acetaminophen Disrupt the Thyroid-Liver Axis in Neonatal Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches
Current Drug Targets Rofecoxib in Patients with Mild Cognitive Impairment: Further Analyses of Data from a Randomized, Double-Blind, Trial
Current Alzheimer Research Sample Preparation Techniques for Mass Spectrometry in Proteomics Using Recently Developed Highly Selective Materials
Current Proteomics Alcoholic Liver Disease: from CYP2E1 to CYP2A5
Current Molecular Pharmacology New Electrocardiographic Features in Brugada Syndrome
Current Cardiology Reviews Catechol-O-methyltransferase, Cognition and Alzheimer's Disease
Current Alzheimer Research A Primary Reduced TCA Flux Governs Substrate Oxidation in T2D Skeletal Muscle
Current Diabetes Reviews The Evolving Therapy of Rheumatic Diseases, The Future is Now
Current Drug Targets - Immune, Endocrine & Metabolic Disorders Physiological and Morphological Principles Underpinning Recruitment of the Cerebellar Reserve
CNS & Neurological Disorders - Drug Targets Towards More Efficient Glutathione Peroxidase Mimics: Substrate Recognition and Catalytic Group Assembly
Current Medicinal Chemistry Therapeutic Potential of Multifunctional Tacrine Analogues
Current Neuropharmacology Clinical Pharmacokinetics of Ibuprofen Arginine
Current Clinical Pharmacology Preface: Recent Innovation in Chemical Engineering Based on Advanced Materials
Recent Innovations in Chemical Engineering The Neurobiological Mechanisms and Treatments of REM Sleep Disturbances in Depression
Current Neuropharmacology Applications of Indan-1,3-Dione in Heterocyclic Synthesis
Current Organic Synthesis Different Food Odors Control Brain Connectivity in Impulsive Children
CNS & Neurological Disorders - Drug Targets Analgesia in PACU: Nonsteroidal Anti-Inflammatory Drugs
Current Drug Targets Processing of Cholinesterase-like α/β-Hydrolase Fold Proteins: Alterations Associated with Congenital Disorders
Protein & Peptide Letters Potassium Channels as Targets for the Management of Pain
Central Nervous System Agents in Medicinal Chemistry