Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles

M.      Siva Nagi Reddy; B.      Sailaja Kumari; B.      Hari Babu

Abstract

Novel 3,5-disubstituted 1,2,4-oxadiazoles 4a-4j were prepared from commercially available chlorosalicylaldehyde and screened for their cytotoxicity properties using brine shrimp (Artemia salina) bioassay and compared with the standard podophyllotoxin. The oxadiazoles 4a, 4c, 4e and 4h exhibited cytotoxicity activity in the series.

Keywords: 5-chlorosalicylaldehyde, Oxadiazoles, Cytotoxicity, Brine shrimp, Chromene derivatives, Synthesis, tyrosine kinase inhibitors, anti-inflammatory agents, Chromene derivatives, cytotoxicity properties

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Letters in Drug Design & Discovery

Title:Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles

Volume: 9 Issue: 10

Author(s): M. Siva Nagi Reddy, B. Sailaja Kumari and B. Hari Babu

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Abstract: Novel 3,5-disubstituted 1,2,4-oxadiazoles 4a-4j were prepared from commercially available chlorosalicylaldehyde and screened for their cytotoxicity properties using brine shrimp (Artemia salina) bioassay and compared with the standard podophyllotoxin. The oxadiazoles 4a, 4c, 4e and 4h exhibited cytotoxicity activity in the series.

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Siva Nagi Reddy M., Sailaja Kumari B. and Hari Babu B., Synthesis and Cytotoxicity Evaluation of Some Novel 3,5-disubstituted- 1,2,4-Oxadiazoles, Letters in Drug Design & Discovery 2012; 9 (10) . https://dx.doi.org/10.2174/1570180811209050942