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Drug Delivery Letters

Editor-in-Chief

ISSN (Print): 2210-3031
ISSN (Online): 2210-304X

Multi Stage Strategy to Reduce Friability of Directly Compressed Orally Disintegrating Tablets

Author(s): Ali Al-Khattawi, Ahmad Aly, Yvonne Perrie, Peter Rue and Afzal R Mohammed

Volume 2, Issue 3, 2012

Page: [195 - 201] Pages: 7

DOI: 10.2174/2210304x11202030195

Price: $65

Abstract

The aim of the presented work describes the formulation of compressed orally disintegrating tablet (ODT) using α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a binder/disintegrant. Preliminary investigations were focused on process and formulation optimisation which resulted in ODT containing 2% wt. TPGS with reasonable hardness and acceptable disintegration time but with high friability. The next stage of the work was to systematically investigate various strategies to overcome high friability including hot-cold cycle of powder blending to promote interparticular adhesion, size separation of diluent, influence of compression force and incorporation of crospovidone. The study concluded that friability was controlled by multi-strategic approach which resulted in reduction from 3.16% to 1%.

Keywords: Direct compression, orally disintegrating tablets, friability, interparticulate, mannitol, particle size, morphology, dysphagia, paediatric, geriatric, pharmaceutical, freeze drying, meticulous, synchronisation, α-tocopheryl.


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