Abstract
Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. With the advancement in the field of chronobiology, modern drug delivery approaches have elevated to a new concept of chronopharmacology i.e. the ability to deliver the therapeutic agent to a patient in a staggered profile. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more sub-disciplines expected to coexist in the near future. Chronopharmaceutics based technology has eliminated the drawbacks associated with the conventional colon specific delivery systems. This review on chronopharmaceutics based delivery lays emphasis on the existing technologies and future development.
Keywords: Colon-targeted delivery, chronopharmaceutics, drug delivery systems, modern technology, drug dosage, chronobiology, drug release, ulcerative colitis, Crohn’s disease, colorectal cancer
Current Drug Discovery Technologies
Title:Chronopharmaceutics Based Modern Colon Specific Drug Delivery Systems
Volume: 9 Issue: 4
Author(s): Akanksha Tiwari, Raj Kumar Shukla, Suresh Tiwari and Surti Naazneen
Affiliation:
Keywords: Colon-targeted delivery, chronopharmaceutics, drug delivery systems, modern technology, drug dosage, chronobiology, drug release, ulcerative colitis, Crohn’s disease, colorectal cancer
Abstract: Colon-targeted delivery of bioactives has recently gained importance in addressing specific needs in the therapy of colon based diseases. Many approaches have been attempted for the development of colon-specific delivery systems, with not much success in the past. With the advancement in the field of chronobiology, modern drug delivery approaches have elevated to a new concept of chronopharmacology i.e. the ability to deliver the therapeutic agent to a patient in a staggered profile. The increasing research interest surrounding this delivery system has widened the areas of pharmaceutics in particular with many more sub-disciplines expected to coexist in the near future. Chronopharmaceutics based technology has eliminated the drawbacks associated with the conventional colon specific delivery systems. This review on chronopharmaceutics based delivery lays emphasis on the existing technologies and future development.
Export Options
About this article
Cite this article as:
Tiwari Akanksha, Kumar Shukla Raj, Tiwari Suresh and Naazneen Surti, Chronopharmaceutics Based Modern Colon Specific Drug Delivery Systems, Current Drug Discovery Technologies 2012; 9 (4) . https://dx.doi.org/10.2174/157016312803305889
DOI https://dx.doi.org/10.2174/157016312803305889 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
A Validated HPLC-PDA Method for the Analysis of Ursolic Acid Content in Poly(lactic acid) Nanoparticles
Current Chromatography Obstructive Sleep Apnea and Cardiovascular Disease - A New Target for Treatment
Current Pharmaceutical Design Global Life-Long Health Benefits of Repression of Hypothalamic NPY System by Central Leptin Gene Therapy
Current Topics in Medicinal Chemistry The Novel Synthesized Pyridazinone Derivates had the Antiproliferative and Apoptotic Effects in SHSY5Y and HEP3B Cancer Cell Line
Letters in Organic Chemistry Meet Our Editor:
Current Hypertension Reviews Vascularization of Biomaterials for Bone Tissue Engineering: Current Approaches and Major Challenges
Current Angiogenesis (Discontinued) Evaluation of Clinical Efficacy of Fasudil for the Treatment of Pulmonary Arterial Hypertension
Recent Patents on Cardiovascular Drug Discovery A Pilot Study to Assess Adenosine 5’-triphosphate Metabolism in Red Blood Cells as a Drug Target for Potential Cardiovascular Protection
Cardiovascular & Hematological Disorders-Drug Targets Uric Acid and Hypertension
Current Pharmaceutical Design Editorial (Thematic Issue: Polypharmacology in Drug Discovery)
Current Pharmaceutical Design Enzymes Inhibition and Antidiabetic Effect of Isolated Constituents from Callistemon lanceoalatus
The Natural Products Journal From the RB Tumor Suppressor to MCR Peptides
Protein & Peptide Letters Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Clinical Approach)
Current Hypertension Reviews Cardiotoxicity of Tyrosine-Kinase-Targeting Drugs
Cardiovascular & Hematological Agents in Medicinal Chemistry Conference Report (8th Annual Meeting of the Society for the Study of Neuroprotection and Neuroplasticity)
CNS & Neurological Disorders - Drug Targets Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies
Current Drug Metabolism Pigment Epithelium-Derived Factor (PEDF): Its Potential Therapeutic Implication in Diabetic Vascular Complications
Current Drug Targets A Possible Placental Factor for Preeclampsia: sFlt-1
Current Medicinal Chemistry Aortic Arch Calcification and Mortality in Chronic Hemodialysis Patients
Reviews on Recent Clinical Trials Meet Our Editorial Board Member:
Current Drug Safety