Synthesis, Antibacterial and Antifungal Activities of Novel N,N’-bipyrazole Piperazine Derivatives

Title:Synthesis, Antibacterial and Antifungal Activities of Novel N,N’-bipyrazole Piperazine Derivatives

Volume: 9 Issue: 9

Author(s): Smaail Radi, Yahya Toubi, Abdelkader Hakkou, Faiza Souna, Imane Himri and Mohammed Bouakka

Affiliation:

Keywords: Piperazine, Pyrazole, Cytotoxicity, Antibacterial, Antifungal activity

Abstract: Novel bipyrazoles possessing a piperazine or a mimed piperazine ring spacer were prepared in one step, in good and excellent yields. The in vitro antibacterial and antifungal activities of these products were screened against two fungal strains (Saccharomyces cerevisiae and Fusarium oxysporum f.sp albedinis) and against bacterial strains (Echerichia coli). Structure-activity relationship (SAR) reflects the effect of substituted drugs. A considerable activity was recorded with respect to the Fusarium oxysporum f.sp albedinis with MIC = 5.0 μg mL-1. All the compounds showed suitable drug-like characteristics according to Lipinski's rule.

Cite this article as:

Radi Smaail, Toubi Yahya, Hakkou Abdelkader, Souna Faiza, Himri Imane and Bouakka Mohammed, Synthesis, Antibacterial and Antifungal Activities of Novel N,N’-bipyrazole Piperazine Derivatives, Letters in Drug Design & Discovery 2012; 9 (9) . https://dx.doi.org/10.2174/157018012803307941