Abstract
Whole-genome studies involving a phenotype of interest are increasingly prevalent, in part due to a dramatic increase in speed at which many high throughput technologies can be performed coupled to simultaneous decreases in cost. This type of genome-scale methodology has been applied to the phenotype of lifespan, as well as to wholetranscriptome changes during the aging process or in mutants affecting aging. The value of high throughput discoverybased science in this field is clearly evident, but will it yield a true systems-level understanding of the aging process? Here we review some of this work to date, focusing on recent findings and the unanswered puzzles to which they point. In this context, we also discuss recent technological advances and some of the likely future directions that they portend.
Keywords: Aging, Genomic, High-throughput, Lifespan, Whole-genome, Yeast, C. elegans
Current Genomics
Title:Genome-Scale Studies of Aging: Challenges and Opportunities
Volume: 13 Issue: 7
Author(s): Mark A. McCormick and Brian K. Kennedy
Affiliation:
Keywords: Aging, Genomic, High-throughput, Lifespan, Whole-genome, Yeast, C. elegans
Abstract: Whole-genome studies involving a phenotype of interest are increasingly prevalent, in part due to a dramatic increase in speed at which many high throughput technologies can be performed coupled to simultaneous decreases in cost. This type of genome-scale methodology has been applied to the phenotype of lifespan, as well as to wholetranscriptome changes during the aging process or in mutants affecting aging. The value of high throughput discoverybased science in this field is clearly evident, but will it yield a true systems-level understanding of the aging process? Here we review some of this work to date, focusing on recent findings and the unanswered puzzles to which they point. In this context, we also discuss recent technological advances and some of the likely future directions that they portend.
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Cite this article as:
A. McCormick Mark and K. Kennedy Brian, Genome-Scale Studies of Aging: Challenges and Opportunities, Current Genomics 2012; 13 (7) . https://dx.doi.org/10.2174/138920212803251454
DOI https://dx.doi.org/10.2174/138920212803251454 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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