Abstract
Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will provide an overview of the action and effects of these hormones in lung, their mechanism of action through their intracellular receptors and their influence over asthma, cystic lung diseases and cancer.
Keywords: Estradiol, estrogen receptor, lung, progesterone, progesterone receptor, ER-α, protein–antibody, colony-stimulating factor, edema
Mini-Reviews in Medicinal Chemistry
Title:Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology
Volume: 12 Issue: 11
Author(s): A. Gonzalez-Arenas and J. Agramonte-Hevia
Affiliation:
Keywords: Estradiol, estrogen receptor, lung, progesterone, progesterone receptor, ER-α, protein–antibody, colony-stimulating factor, edema
Abstract: Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will provide an overview of the action and effects of these hormones in lung, their mechanism of action through their intracellular receptors and their influence over asthma, cystic lung diseases and cancer.
Export Options
About this article
Cite this article as:
Gonzalez-Arenas A. and Agramonte-Hevia J., Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology, Mini-Reviews in Medicinal Chemistry 2012; 12 (11) . https://dx.doi.org/10.2174/138955712802762194
DOI https://dx.doi.org/10.2174/138955712802762194 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
An Overview on Natural Polysaccharides with Antioxidant Properties
Current Medicinal Chemistry Pharmaceutical and Histopathological Analyses of the Developing Mechanism of Severe Allergic Conjunctival Diseases Using Experimental Animal Models: Roles of Systemic and Local Cytokines
Current Pharmaceutical Analysis Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing Agents
Anti-Cancer Agents in Medicinal Chemistry Adherence in Asthma
Current Respiratory Medicine Reviews <i>Nigella sativa</i>, as Preventive Strategy in COVID-19
Current Traditional Medicine Antagonists of CCR4 as Immunomodulatory Agents
Current Topics in Medicinal Chemistry Searching the Staphylococcal Toxic Shock Syndrome Toxin -1 in Septic Children with negative Cultures: A Comparative Study in Tehran, Iran
Infectious Disorders - Drug Targets Catalytic Activity of Certain Antibodies as a Potential Tool for Drug Synthesis and for Directed Prodrug Therapies
Current Medicinal Chemistry Biomarkers in Pediatric Lung Diseases Including Cystic Fibrosis
Current Respiratory Medicine Reviews Editorial [Hot Topic: An Update on Neurotrophins (Guest Editor: Celia Duarte Cruz)]
Current Neuropharmacology Transdermal Buprenorphine-A Novel Medication for Postoperative Pain Management Following Abdominal Hysterectomy for Benign Gynecological Conditions
Current Women`s Health Reviews Docking Prediction for Luteolin Inhibiting TNF-α and NF-κB Pathway
Letters in Drug Design & Discovery High Cytotoxicity and Apoptotic Effects of Natural Bioactive Benzofuran Derivative on the MCF-7 Breast Cancer Cell Line
Combinatorial Chemistry & High Throughput Screening Pharmacological Evaluation of Antiasthmatic Activity of Myrica nagi Bark Extracts
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Patent Selections
Recent Patents on Inflammation & Allergy Drug Discovery Eosinophils, a Jack of All Trades in Immunity: Therapeutic Approaches for Correcting Their Functional Disorders
Endocrine, Metabolic & Immune Disorders - Drug Targets Metal Oxide Nanostructures for Solid State Gas Sensors: A Recent Patent Survey
Recent Patents on Materials Science Thiazole-based Chalcone Derivatives as Potential Anti-inflammatory Agents: Biological Evaluation and Molecular Modelling
Current Topics in Medicinal Chemistry Antiinflammatory Effects of H1-Antihistamines: Clinical and Immunological Relevance
Current Pharmaceutical Design Chronopharmaceutics Based Modern Colon Specific Drug Delivery Systems
Current Drug Discovery Technologies