Synthesis and Antifungal Activity of 3-Substituted-thiochroman-4-one Semicarbazone Derivatives

Title:Synthesis and Antifungal Activity of 3-Substituted-thiochroman-4-one Semicarbazone Derivatives

Volume: 9 Issue: 8

Author(s): Hong-jian Geng, Zhao-bin Xing, Wei Luo, Ling Cong, Xin-yu Li and Chun Guo

Affiliation:

Keywords: 3-substituted-thiochroman-4-one semicarbazone, Synthesis, Antifungal activity, 4-substituted-semicarbazides, thiochromanones, semicarbazone, Fluconazole, fungal reproduction, thiochromanones moiety

Abstract: A series of 3-substituted-thiochroman-4-one semicarbazone derivatives were designed based on the bioisosterism and combination principle in drug design. The target compounds were prepared from 3-substitutedthiochroman- 4-one (1) and 4-substituted-semicarbazides( 2), their structures were confirmed by MS and 1H NMR. The antifungal assay was carried out in vitro by twofold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.

Cite this article as:

Geng Hong-jian, Xing Zhao-bin, Luo Wei, Cong Ling, Li Xin-yu and Guo Chun, Synthesis and Antifungal Activity of 3-Substituted-thiochroman-4-one Semicarbazone Derivatives, Letters in Drug Design & Discovery 2012; 9 (8) . https://dx.doi.org/10.2174/157018012802652903