Abstract
Breast cancer is the second-leading cause of cancer death among women in the United States, alone. Many papers throughout the past and current medical literature have shown it is strongly associated with the reproductive axis and the growth hormone axis. Ghrelin is a pleiotropic 28-aminoacidic hormone and an integrated component of the GH axis, which is implicated in breast cancer risk factors. There has never been published a systematic review about ghrelin, its receptor and gene and their relation to breast cancer till this day, to our knowledge. The main goal of this systematic review is to explore the aforementioned relationship in perspective to new therapeutic targets. A systematic review of relevant studies by searching the PubMed and the SciVerse Scopus databases was performed retrieving four (4) experimental studies, three (3) cohort and one (1) case-control study, which were included in the present systematic review, out of 63 papers. Ghrelin is definitely an auspicious candidate molecule for breast cancer prevention, detection and therapy. Future studies should be encouraged to investigate ghrelin axis on breast cancer pathogenesis and/or tumorigenesis, which hopefully would give results in difficult breast cancer cases, such as in reproductive females.
Keywords: Ghrelin, breast cancer, novel therapeutic targets, hormonal levels, pathophysiologic mechanisms, 28-aminoacidic hormone, mammography, progesterone, oestrogen, pathogenesis
Current Signal Transduction Therapy
Title:The Role of Ghrelin Signals in Breast Cancer- A Systematic Review
Volume: 7 Issue: 3
Author(s): Charikleia Stefanaki, Filippos-Paschalis Rorris and Michael Stamatakos
Affiliation:
Keywords: Ghrelin, breast cancer, novel therapeutic targets, hormonal levels, pathophysiologic mechanisms, 28-aminoacidic hormone, mammography, progesterone, oestrogen, pathogenesis
Abstract: Breast cancer is the second-leading cause of cancer death among women in the United States, alone. Many papers throughout the past and current medical literature have shown it is strongly associated with the reproductive axis and the growth hormone axis. Ghrelin is a pleiotropic 28-aminoacidic hormone and an integrated component of the GH axis, which is implicated in breast cancer risk factors. There has never been published a systematic review about ghrelin, its receptor and gene and their relation to breast cancer till this day, to our knowledge. The main goal of this systematic review is to explore the aforementioned relationship in perspective to new therapeutic targets. A systematic review of relevant studies by searching the PubMed and the SciVerse Scopus databases was performed retrieving four (4) experimental studies, three (3) cohort and one (1) case-control study, which were included in the present systematic review, out of 63 papers. Ghrelin is definitely an auspicious candidate molecule for breast cancer prevention, detection and therapy. Future studies should be encouraged to investigate ghrelin axis on breast cancer pathogenesis and/or tumorigenesis, which hopefully would give results in difficult breast cancer cases, such as in reproductive females.
Export Options
About this article
Cite this article as:
Stefanaki Charikleia, Rorris Filippos-Paschalis and Stamatakos Michael, The Role of Ghrelin Signals in Breast Cancer- A Systematic Review, Current Signal Transduction Therapy 2012; 7 (3) . https://dx.doi.org/10.2174/157436212802481547
DOI https://dx.doi.org/10.2174/157436212802481547 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs
Anti-Cancer Agents in Medicinal Chemistry Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters
Current Drug Metabolism Polyphenols of Carménère Grapes
Mini-Reviews in Organic Chemistry Editorial [Hot topic: Developing New Anti-Cancer Drugs (Guest Editor: Ricardo De Souza Pereira)]
Recent Patents on Anti-Cancer Drug Discovery Combined Therapies of Bone Disease with Bisphosphonates
Current Pharmaceutical Design Dietary Phenolic Acids and Flavonoids as Potential Anti-Cancer Agents: Current State of the Art and Future Perspectives
Anti-Cancer Agents in Medicinal Chemistry Organosulfur Compounds in Cancer Chemoprevention
Mini-Reviews in Medicinal Chemistry Antitumoral-Lipid-Based Nanoparticles: a Platform for Future Application in Osteosarcoma therapy
Current Pharmaceutical Design Combining Drug-Loaded Nanobubbles and Extracorporeal Shock Waves for Difficult-to-Treat Cancers
Current Drug Delivery Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines
Current Molecular Pharmacology Outcome-Dependent Global Similarity Analysis of Imbalanced Core Signaling Pathways in Ischemic Mouse Hippocampus
CNS & Neurological Disorders - Drug Targets A Review on Fruit Juice Probiotication: Pomegranate
Current Nutrition & Food Science Tumour-Derived Glutamate: Linking Aberrant Cancer Cell Metabolism to Peripheral Sensory Pain Pathways
Current Neuropharmacology An Electrochemical Outlook on Tamoxifen Biotransformation: Current and Future Prospects
Current Drug Metabolism PDGF-D Signaling: A Novel Target in Cancer Therapy
Current Drug Targets Fyn Kinase in Brain Diseases and Cancer: The Search for Inhibitors
Current Medicinal Chemistry Hormonal Therapy for Prostate Cancer: Toward Further Unraveling of Androgen Receptor Function
Anti-Cancer Agents in Medicinal Chemistry Antibacterial Peptides and Gastrointestinal Diseases
Current Pharmaceutical Design Farnesyltransferase Inhibitors: A Detailed Chemical View on an Elusive Biological Problem
Current Medicinal Chemistry Fusion of Wavelet and Morphological Features for Breast Cancer Diagnosis in Ultrasound Images
Current Medical Imaging