Abstract
The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.
Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant
Letters in Organic Chemistry
Title:Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines
Volume: 9 Issue: 7
Author(s): Majid Ghashang
Affiliation:
Keywords: Diastereoselectivity, functionalized piperidines, metal hydrogen sulfate, zinc hydrogen sulfate [Zn(HSO4)2], Donepezil, Sertindole, Risperidone, anti-inflammatory, anti-hypertensive, anti-convulsant
Abstract: The preparation of substituted piperidines via three-component reaction between aldehydes, aromatic amines and acetoacetic esters has been developed. The process has been carried out under ambient conditions in the presence of zinc hydrogen sulfate [Zn(HSO4)2]. A variety of aldehydes and amines were yielded into the corresponding products demonstrating the versatility of the reaction.
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Cite this article as:
Ghashang Majid, Zinc Hydrogen Sulfate Promoted Multi-component Preparation of Highly Functionalized Piperidines, Letters in Organic Chemistry 2012; 9 (7) . https://dx.doi.org/10.2174/157017812802139564
DOI https://dx.doi.org/10.2174/157017812802139564 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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