Abstract
Central nervous system pericytes have critical and complex inductive, structural, and regulatory roles interacting with other cell types of the neurovascular unit, especially endothelial cells and astrocytes. Pericyte-endothelial interactions are particularly prominent for blood-brain barrier (BBB) maintenance, with profound effects on basement membrane and endothelial tight junction structure and function. Under experimental conditions of hypoxia-ischemia mimicking stroke, pericytes migrate from their usual microvascular location and influence, directly or indirectly, BBB permeability. The contractile properties of pericytes provide the capacity to regulate capillary blood flow, but this may have detrimental effects on ischemic injury. Stem cell characteristics of pericytes imply an important regenerative role following stroke. Pericytes thus appear to orchestrate multiple critical functions in stroke, involving blood flow, permeability, and repair of the neurovascular unit.
Keywords: Pericyte, endothelium, astrocyte, microvasculature, blood-brain barrier, neurovascular unit, stroke, BBB permeability, ischemic injury, blood flow.
Current Pharmaceutical Design
Title:The Role of Pericytes in Blood-Brain Barrier Function and Stroke
Volume: 18 Issue: 25
Author(s): Shuo Liu, Dritan Agalliu, Chuanhui Yu and Mark Fisher
Affiliation:
Keywords: Pericyte, endothelium, astrocyte, microvasculature, blood-brain barrier, neurovascular unit, stroke, BBB permeability, ischemic injury, blood flow.
Abstract: Central nervous system pericytes have critical and complex inductive, structural, and regulatory roles interacting with other cell types of the neurovascular unit, especially endothelial cells and astrocytes. Pericyte-endothelial interactions are particularly prominent for blood-brain barrier (BBB) maintenance, with profound effects on basement membrane and endothelial tight junction structure and function. Under experimental conditions of hypoxia-ischemia mimicking stroke, pericytes migrate from their usual microvascular location and influence, directly or indirectly, BBB permeability. The contractile properties of pericytes provide the capacity to regulate capillary blood flow, but this may have detrimental effects on ischemic injury. Stem cell characteristics of pericytes imply an important regenerative role following stroke. Pericytes thus appear to orchestrate multiple critical functions in stroke, involving blood flow, permeability, and repair of the neurovascular unit.
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Cite this article as:
Liu Shuo, Agalliu Dritan, Yu Chuanhui and Fisher Mark, The Role of Pericytes in Blood-Brain Barrier Function and Stroke, Current Pharmaceutical Design 2012; 18 (25) . https://dx.doi.org/10.2174/138161212802002706
DOI https://dx.doi.org/10.2174/138161212802002706 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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