Abstract
Chromones are an important group of heterocyclic compounds due to their important functions in nature and their pharmacological applications. Many efficient syntheses of chromones have been reported through the years but the search for novel methods addressing to the preparation of this type of compounds still remains a relevant topic. Simple and efficient procedures using molecular iodine for the synthesis of these organic molecules have been reported. The uses of catalytic amounts of iodine in cyclodehydration reactions and as additives in oxidative or photooxidative cyclizations are well known approaches for the preparation of new chromone-type compounds. The purpose of this review is to describe the most relevant work on chromone-type compounds using molecular iodine.
Keywords: Flavones, molecular iodine, oxidative cyclizations, 2-styrylchromones, (E)-2-styrylchromone, rhizomes, demonstrated cytotoxic activity, styrylchromone.
Current Organic Synthesis
Title:Molecular Iodine in the Synthesis of Chromone-type Compounds
Volume: 9 Issue: 4
Author(s): Diana C.G.A. Pinto and Artur M.S. Silva
Affiliation:
Keywords: Flavones, molecular iodine, oxidative cyclizations, 2-styrylchromones, (E)-2-styrylchromone, rhizomes, demonstrated cytotoxic activity, styrylchromone.
Abstract: Chromones are an important group of heterocyclic compounds due to their important functions in nature and their pharmacological applications. Many efficient syntheses of chromones have been reported through the years but the search for novel methods addressing to the preparation of this type of compounds still remains a relevant topic. Simple and efficient procedures using molecular iodine for the synthesis of these organic molecules have been reported. The uses of catalytic amounts of iodine in cyclodehydration reactions and as additives in oxidative or photooxidative cyclizations are well known approaches for the preparation of new chromone-type compounds. The purpose of this review is to describe the most relevant work on chromone-type compounds using molecular iodine.
Export Options
About this article
Cite this article as:
C.G.A. Pinto Diana and M.S. Silva Artur, Molecular Iodine in the Synthesis of Chromone-type Compounds, Current Organic Synthesis 2012; 9 (4) . https://dx.doi.org/10.2174/157017912802651429
DOI https://dx.doi.org/10.2174/157017912802651429 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Ulcerative Colitis: Pathogenesis
Current Drug Targets Caveats Regarding the Use of IL-10 and IL-10 Antagonist as Immunotherapeutic Factors
Letters in Drug Design & Discovery Anti-Inflammatory Properties of Acetylcholinesterase Inhibitors Administred in Alzheimers Disease
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Therapeutic Potential of Endothelial Progenitor Cells for Cardiovascular Diseases
Current Vascular Pharmacology Mood, Memory and Movement: An Age-Related Neurodegenerative Complex?
Current Aging Science Nutritional Attributes and Health Application of Seabuckthorn (<i>Hippophae rhamnoides</i> L.) – A Review
Current Nutrition & Food Science Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems?
Current Drug Targets Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Current Medicinal Chemistry Current Strategies in TB Immunotherapy
Current Molecular Medicine The ERK and p38MAPK Pathways as Targets for Anti-Inflammatory Therapy
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Clinical Pharmacogenetics and Potential Application in Personalized Medicine
Current Drug Metabolism Targeted Delivery of Tumor Suppressor microRNA-1 by Transferrin- Conjugated Lipopolyplex Nanoparticles to Patient-Derived Glioblastoma Stem Cells
Current Pharmaceutical Biotechnology <i>In Vivo</i> Anti-Tumor Effects of Flavokawain A in 4T1 Breast Cancer Cell-Challenged Mice
Anti-Cancer Agents in Medicinal Chemistry Antioxidants as a Potential Preventive and Therapeutic Strategy for Cadmium
Current Drug Targets Nuclear Membranes GPCRs: Implication in Cardiovascular Health and Diseases
Current Vascular Pharmacology Myocardial Expression of TNF-α, IL-1β, IL-6, IL-8, IL-10 and MCP-1 After a Single MDMA Dose Administered in a Rat Model
Current Pharmaceutical Biotechnology Recent Advances in the Development of Multi-Kinase Inhibitors
Mini-Reviews in Medicinal Chemistry Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications
Current Topics in Medicinal Chemistry Structural and Functional Diversity Among Eukaryotic Hsp70 Nucleotide Exchange Factors
Protein & Peptide Letters How do Glial Cells Contribute to Motor Control?
Current Pharmaceutical Design