ACKNOWLEDGEMENT TO REVIEWERS

Author(s):

Journal Name: Current Respiratory Medicine Reviews

Volume 16 , Issue 4 , 2020

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VOLUME: 16
ISSUE: 4
Year: 2020
Published on: 26 February, 2021
Page: [263 - 263]
Pages: 1
DOI: 10.2174/1573398X1604210226234051
Price: $65


Current Respiratory Medicine Reviews

Editor-in-Chief:

Joseph Varon  
The University of Texas Health Science Center
Houston, TX
USA

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Echopulmonography as a Surrogate Modality in Disclosure of Occult Pulmonary Consequences of Pulmonary Vascular Occlusion

Pp: 220-227
Ahmed Mohammed Abumossalam, Marwa Mohammed Nashat El Mekkawy, Raed Elmetwally Ali Eid, Mohamed Salah and Ahmed Ehab*
DOI: 10.2174/1573398X17666210129123946

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Clinical and Quality of Life Differences in Patients with COPD With and Without a Background of Hospitalization in the Last Year

Pp: 228-233
Jhonatan Betancourt-Peña*, Juan Carlos Ávila-Valencia, Jorge Karim Assis and David Alejandro Escobar-Vidal
DOI: 10.2174/1573398X17666210209111111

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The Role of LVOT-VTI Measurement in the Evaluation of Systolic Heart Function in Pulmonary ICU Patients

Pp: 234-239
Meltem Çimen, Selin Eyüboğlu, Uğur Özdemir*, Burhan Sami Kalın, Tuba Güney and Gül Gürsel
DOI: 10.2174/1573398X16999201222123512

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Montelukast Efficacy for Improvement of Adult Acute Phase Mild-Moderate Asthma Attack: A Clinical Trial Study

Pp: 246-251
Hassan Motamed, Mohammadreza Maleki Verki*, Hasan Barzegari, Siamak Shariat and Saeed Hesam
DOI: 10.2174/1573398X17666210204164717

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Comparison the Effect of Arbidol Plus Hydroxychloroquine vs Hydroxychloroquine Alone in Treatment of COVID-19 Disease: A Randomized Clinical Trial

Pp: 252-262
Rozita Khodashahi, Hamidreza Naderi, Amin Bojdy, Ali Akbar Heydari, Ashraf Tavanaee Sani, Mohammad Javad Ghabouli, Mohammad Reza Sarvghad, Mahboubeh Haddad Nateghi, Mahnaz Arian, Shahrzad Jahanian, Saeedeh Mazidi, Maziar Mortazavi Pasand, Binyamin Hoseini, Maliheh Dadgarmoghaddam, Ali Khorsand and Mandana Khodashahi*
DOI: 10.2174/1573398X17666210129125703

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From Pituitary Adenoma to Pituitary Neuroendocrine Tumors: How Molecular Pathways may Impact on the Therapeutic Management?

(E-pub Abstract Ahead of Print)

Author(s): Sabrina Chiloiro, Laura De Marinis*

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Abstract:

The classification of adeno-pituitary tumor was deeply revised over the last 20 years, in order to better describe the variable and complex biological and the clinical behavior of these neoplasia and to identify prognostic markers of aggressiveness and poor prognosis. Recently, the International Pituitary Pathology Club proposed to replace the term “pituitary adenoma” with “pituitary neuroendocrine tumour” (PitNET), to reflect similarities of adeno-pituitary tumours with neuroendocrine neoplasia of other organs, underling better the variable behaviour of adeno-pituitary neoplasia. A definitive consensus was not reach on this issue. In this review, we will describe the how molecular and biological marker can predict aggressiveness of PitNETs and impact on therapeutic management of PitNETs.

Keywords: Hyperprolactinemia, prolactinoma, acromegaly, Cushing, hypercortisolism, gonadotropinoma, somatostatin receptor, somatostatin analogues.  

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DOI: 10.2174/1871530321666210226152901
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Letters in Organic Chemistry

Editor-in-Chief:

Alberto Marra
University of Montpellier
Montpellier
France

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Synthesis and Antimicrobial Activities of Some Polyphenol Compounds by Nano ZnO-TBAB as a Heterogeneous Catalytic Media

Pp: 203-211
Rahele Bargebid, Ali Khalafi-Nezhad, Kamiar Zomorodian, Leila Zamani, Ali Ahmadinejad and Soghra Khabnadideh*
DOI: 10.2174/1570178617999200517131353

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Synthesis, Evaluation of Biological Activity, Docking and Molecular Dynamic Studies of Pyrimidine Derivatives

Pp: 212-225
Shahin Boumi, Jafar Moghimirad, Massoud Amanlou, Seyed Nasser Ostad, Shohreh Tavajohi and Mohsen Amini*
DOI: 10.2174/1570178617999200706005824

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Urea as an Ammonia Surrogate in the Hantzsch’s Synthesis of Polyhydroquinolines / 1,4-dihydropyridines under Green Reaction Conditions

Pp: 226-232
G. Dhananjaya, Akula Raghunadh, P. Mahesh Kumar, S. Pulla Reddy, V. Narayana Murthy, Venkateswara Rao Anna* and Manojit Pal*
DOI: 10.2174/1570178617999200713144504

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Adhatoda vasica (Nees.): A review on its botany, traditional uses, phytochemistry, pharmacological activities and toxicity

(E-pub Abstract Ahead of Print)

Author(s): Tahmida Shamsuddin, Muhammad Shaiful Alam, Md. Junaid, Rasheda Akter, S. M. Zahid Hosen, Sakia Ferdousy, Nusrat Jahan Mouri*

Journal Name: Mini-Reviews in Medicinal Chemistry

Abstract:

Background: Adhatoda vasica (Nees.) of family Acanthaceae has been used in the Southeast tropical zone as it is efficacious against headache, colds, cough, whooping cough, fever, asthma, dyspnea, phthisis, jaundice, chronic bronchitis and diarrhea and exhibits commendable pharmacological activities.

Objective: The aim of the review is to provide a systematic overview of pharmacological activities with toxicity and clinical assessment, phytochemistry of A. vasica along with its characterization, geographical observation, phenology, traditional uses as well as an organized representation of the findings.

Method: The overall information of A. vasica were collected from various resources including books, review papers, research papers and reports which were obtained by an online search of worldwide-accepted scientific databases. ChemDraw software was used to draw the compounds’s structure.

Results: Phytochemical review on A. vasica has led to the collection of 233 compounds of different types such as alkaloids, flavonoids, essential oils, terpenoids, fatty acids, phenols etc. It is a promising source of phytopharmaceutical potential agent that exhibits diverse pharmacological activities including antibacterial, antifungal, hepatoprotective, anti-ulcer, abortifacient, antiviral, anti-inflammatory, thrombolytic, hypoglycemic, anti-tubercular, antioxidant and antitussive activities.

Conclusions: The sufficient number of studies on ethno-pharmacology, traditional uses and pharmacological activities of A. vasica are conducted. Furthermore, it is necessary to study the activity of chemical constituents for new drug design and discovery from natural products.

Keywords: Adhatoda vasica, Acanthaceae, Traditional uses, Phytochemistry, Pharmacological activity, Phytochemical review

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DOI: 10.2174/1389557521666210226152238
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Patent Selections

Author(s):

Journal Name: Recent Patents on Engineering

Volume 15 , Issue 3 , 2021

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VOLUME: 15
ISSUE: 3
Year: 2021
Page: [404 - 404]
Pages: 1
DOI: 10.2174/187221211503210226151554




Update on acrylic resins used in dentistry

(E-pub Abstract Ahead of Print)

Author(s): Zbigniew Raszewski, Agnieszka Nowakowska-Toporowska*, Danuta Nowakowska, Włodzimierz Więckiewicz

Journal Name: Mini-Reviews in Medicinal Chemistry

Abstract:

Acrylic resins are the most commonly used materials in prosthetics and orthodontics until now. They have a well-documented history of use as biomaterials in the manufacture of different types of dental appliances. The objective of this study was to describe the properties of acrylic resins and the processing methods used for these materials in dentistry. The review depicts the most important achievements in this area, indicating that the resin technology evolved in different directions. The mechanical and biological properties of acrylic resins were improved by the addition of mineral or natural fibers, and/or fillers including nanofillers, as well as by poly(methyl methacrylate) surface modification. The presence of residual monomer was reduced as a result of postpolymerization activity. New types of acrylic resins were developed for processing Computer-Aided Design/Computer-Aided Manufacturing systems and three-dimensional printing.

Keywords: acrylic resin, denture base, anti-infective agents, nanofillers, surface modification

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DOI: 10.2174/1389557521666210226151214
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PROTACs in Treatment of Cancer: A review

(E-pub Abstract Ahead of Print)

Author(s): Poonam Arora, Manjinder Singh, Varinder Singh, Shiveena Bhatia, Sandeep Arora*

Journal Name: Mini-Reviews in Medicinal Chemistry

Abstract:

Cancer treatment has become a major challenge amidst the resistance and relapse caused by the various treatments available. The PROteolysis TAargeting Chimera (PROTAC) technology involves the degradation of target protein against the inhibition by small drug molecules. The PROTACs with high potency and activity have been frequently reported; however, no PROTAC acting against cancer has reached the clinical trials so far. The concept of PROTACs involves the reduction in the disease causing protein by its degradation through ubiquitin-proteosomal enzyme system. This concept has attracted a lot of attention from both industry and academia due to its potential in drug discovery (in the form of PROTACs) which can conquer the resistance associated with current treatments of cancer. Thus, it is the need of hour to identify and synthesize more PROTACs for a viable treatment of cancer. This article reviews the design, activity and the effects produced in cancer by some recently developed PROTACs.

Keywords: PROTACs, Cancer, Ubiquitin, Anticancer, Proteins, Target

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(E-pub Abstract Ahead of Print)
DOI: 10.2174/1389557521666210226150740
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1,3,4-Oxadiazole Containing Compounds As Therapeutic Targets For Cancer Therapy

(E-pub Abstract Ahead of Print)

Author(s): Mohamed Jawed Ahsan*

Journal Name: Mini-Reviews in Medicinal Chemistry

Abstract:

Background: Cancer is the first or second leading cause of premature death in 134 of 183 countries in the world. 1,3,4-Oxadiazoles are five memebered heterocyclic rings containing two nitrogen (two atoms) and oxygen (one atom). They show better thermal stability, metabolic stability, aqueous solubility and lower lipophilicity than the other isomeric oxadiazoles. They are important class of heterocycles present in many drug structures like Raltegravir, Furamizole Tidazosin, Nesapidil, Setileuton (MK-0633) and Zibotentan. Presence of this nucleus in the therapeutics has made them an indispensable anchor for drug design and development. Several 1,3,4-oxadiazoles are prepared and reported as anticancer agents by numerous scientists worldwide.

Objectives: The present review discusses the anticancer potentials together with the molecular targets of 1,3,4-oxadiazoles reported since 2010. The structure activity relationship (SAR) and molecular docking simulation on different targets have also been discussed herein. Some of the important cancer targets have also been explored.

Methods: The most potent 1,3,4-oxadiazoles reported in literature was highlighted in the manuscript. The anticancer activity was reported in terms of growth percent (GP), percent growth inhibition (%GI), GI50, IC50, and LC50 and TGI.

Results: 1,3,4-Oxadiazoles are an important heterocyclic scaffolds with broad spectrum biological activities. They may be either mono substituted or disubstituted and act as an indispensable anchor for drug design and discovery due to their thermal stability together with low lipophilicity. They exhibited anticancer potentials and showed the inhibitions of various cancer targets.

Conclusion: The discussion outlined herein will proved to be a helpful and vital tool for medicinal chemists investigating and working with 1,3,4-oxadiazoles and anticancer research programs.

Keywords: Anticancer, Antiproliferative, Cytotoxicity, 1, 3, 4-Oxadiazoles, Structure activity relationship (SAR), Molecular docking

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DOI: 10.2174/1389557521666210226145837
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Insights into newly approved drugs from a medicinal chemistry perspective

(E-pub Abstract Ahead of Print)

Author(s): Elys Juliane Cardoso Lima, Renan Augusto Gomes, Evelin Fornari, Flavio da Silva Emery, Gustavo Henrique Goulart Trossini*

Journal Name: Mini-Reviews in Medicinal Chemistry

Abstract:

The development of new drugs is becoming notably harder each decade. To overcome the present pitfalls in the drug development pipeline, such as those related to potency, selectivity, or absorption, distribution, metabolism, excretion and toxicity properties, medicinal chemistry strategies need to be in continuous evolution and need to become even more multidisciplinary. In this review, we present how structure-based, ligand-based, and fragment-based drug design (SBDD, LBDD, and FBDD, respectively) and their respective techniques were used for the design and optimization of successful cases of new molecular entities (NMEs) approved by the Food and Drug Administration (FDA).

Keywords: Drug design, Medicinal chemistry, New molecular entities, FDA-approved drugs, Structure-based drug design, SBDD, Ligand-based drug design, LBDD, Fragment-based drug design, FBDD

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DOI: 10.2174/1389557521666210226145328
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