Natural products have dominated our lives since ancient times. Today, they are an inexhaustible source of new medications for disease treatment. The practice of evaluating bioactive compounds extracted from natural sources has also advanced significantly, prompting a need to understand current methods to identify and evaluate them. This book covers basic scientific aspects of preclinical research on natural products for specific conditions and diseases. These include aging, gynecological disorders, inflammatory disorders, renal disorders and cardiovascular disorders. Each of the 10 book chapters give a structured overview on preclinical methods on the etiology of diseases, natural products as the materials for the bioassays, extract types, concentration of the extracts/compounds for in vitro and in vivo assays, preparation of the test materials, application of the test materials, step-by-step methods and related calculations. The book is intended as a quick reference for natural product researchers, pharmacists and postgraduate students in pharmacognosy. Medical doctors working in preclinical research on natural products will also benefit from the information provided.

Diagnosis and Management of Fetal Disorders reviews key points in obstetrics/maternal fetal medicine imagery analysis of the pregnant uterus and its contents. Specifically, chapters cover ultrasound of different fetal organs, physiological systems and diseases. The authors also provide radiological correlation to help the obstetrician, pediatrician, radiologist, and other specialists know the basics and some more advanced concepts that will allow diagnosis of fetal abnormality, and what those findings mean to the patient and their families vis-a-vis the fetus in their pregnancy. It is ,therefore, a handbook that helps medical residents and professionals to assess cases in real-time or to review a given clinical problem. Key Features - 13 structured chapters covering key topics related to the ultrasound of different fetal organs, physiological systems and diseases - Evidence-based presentation through detailed images and references - Portability and practical information on general and differential diagnostics to consider in fetal and uterine examinations. - Useful information for medical and genetic counseling affected mothers and couples The book is intended for a broad readership in medicine including medical students, specialty trainees and attending physicians in obstetrics, pediatrics, radiology, and subspecialty trainees in maternal fetal medicine, neonatology, ultrasound imaging. Medical professionals in allied fields including sonography, family practice, and genetic counseling will also benefit from the information presented in the book.

A Case-Based Approach to Interventional Pulmonology: A Focus on Asian Perspectives focuses on various aspects of Interventional Pulmonology (IP) based on clinical case scenarios. Today, evidence-based medicine and statistics are ruling our daily practice. Thus, each case is unique regardless of what the theory predicts. This asian perspective of Interventional Pulmonology (IP) is also of great importance, given the differences in the etiologies compared to other regions of the world. Asia being the leading region in terms of population and the high incidence of certain airway and lung diseases, is an amazing source for fundamental and clinical research. The contents of the book have been divided into four different sections with a primary aim of case-based scenarios and solutions. Section A consists of diagnostic IP procedures like linear and radial EBUS, navigation bronchoscopy, bronchoscopic lung cryobiopsy (BLC) and cone beam CT. Section B focuses on therapeutic rigid bronchoscopic procedures. Besides airway stenting and laser bronchoscopy, this discusses recent interventions such as bronchial thermoplasty, bronchoscopic lung volume reduction, 3D printing and microwave ablation. Section C is dedicated to pleural procedures focusing on indwelling pleural catheters (IPC) and fibrinolytics. Section D is dedicated to common paediatric IP procedures. Each case is presented with the history, including clinical, radiological, bronchoscopic/pleuroscopic findings and final outcomes. Many of these cases also have video illustrations.

COVID-19 has spread like wildfire across the globe since the start of the SARS-CoV-2 outbreak, hampering quality of life at multiple levels and causing many deaths. Many aspects of the human experience have been affected, with a body of research being published on its effects on psychological and physical well being, loss of jobs, pay cuts, education, and unpaid caregiving. New findings on these aspects are still emerging as we learn more about the consequences of the pandemic. This book is intended as a simple summary of recent findings about COVID-19 for academicians and students from science, humanities and commerce backgrounds to understand the pandemic from a microscopic view and how it has touched our lives at different levels. A collection of topics is presented and explored through chapters dedicated to niche topics on COVID-19. Each chapter is authored by expert scientists, academicians and scholars from leading institutions in India. The key features of this book set are: - Interdisciplinary content, making it useful for readers from different academic streams - A blend of basic and applied research in biology, medicine and social science - A focus on findings from India - Updated References for advanced readers This collection of topics is invaluable for researchers and working professionals in industry and academia as well as general readers who want a broad, insightful perspective on COVID-19.

This book explains key concepts and applications of nanotechnology in clinical medicine and pharmacology. The chapters have been contributed by experts and provide a broad perspective about the current and future developments in pharmacology, toxicology, cell biology, and materials science. The book is divided into 2 main sections. The first section concerns nanobiotechnology for human health including gastrointestinal disease, kidney diseases, pulmonary disorders, reproductive system, COVID-19, and cancer. The second section is devoted to toxicological aspects of nanomaterials which involve toxicological assessments of nanotherapeutics and potential solutions for nanotoxicology. Key Features - Emphasizes the high degree of interdisciplinary research in pharmacology, toxicology and nanoscience - Summarizes the results of theoretical, methodological, and practical studies in different medical subspecialties - includes special topics such as novel nanotoxicology assessment methods and nano vaccines - Includes references for further reading

Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The tenth volume of this series features 4 reviews on the following topics: -Pharmacotherapy of Posterior Segment Ocular Infections -Discovery and Development of Antimalarial Drug-Resistance Reversal Agents -Omics Technologies and Anti-Infective Drug Discovery -Possible Cutaneous Adverse Effects of Anti-Infective Vaccinations

Natural Immunomodulators: Promising Therapy for Disease Management discusses the use of natural immunomodulators as a promising therapy for managing various diseases. The book begins with an introduction to the immune system and the ways in which it can be modulated. This is followed by a discussion on the various diseases and disorders associated with the immune system, including autoimmune disorders, allergies, and immune deficiency conditions. The natural sources of immunomodulators, including plants, herbs, and other natural substances is also explained along with the importance of standardizing natural immunomodulator drugs, including the methods used to ensure their quality and consistency. The book also delves into the chemistry and analytical techniques used to study immunomodulators, clinical and pre-clinical bioassays. The next couple of chapters focus on the use of natural immunomodulators in cancer, the therapy of cancer and infectious diseases. Drug delivery and the strategy and regulatory perspective for natural immunomodulators. The final 2 chapters round up the contents with information about synthetic immunomodulators and the future perspective for the use of immunomodulators in disease management. Natural Immunomodulators: Promising Therapy for Disease Management is a comprehensive guide to the use of natural immunomodulators as a therapy for various diseases, and is a valuable resource for professionals and students interested in this topic. The book is aimed at health care professionals such as medical doctors, nurses, pharmacists, and life science and nutritionist professionals, as well as students.

Probiotics have been suggested to be involved in both prevention and treatment of various human cancers. Probiotics in Anticancer Immunity is a set of volumes in the Frontiers in Cancer Immunology series that explains biochemical mechanisms of anticancer immunity exerted by probiotics in various human cancers. It presents edited chapters focused on the evidence of probiotic use against human cancers through several animal and human studies. This volume of Probiotics in Anticancer Immunity consists of 11 chapters. The introductory chapters provide information about the link between gut microbiota and the host immune system in cancer and the general mechanisms of anticancer immunity exerted by probiotics. Subsequent chapters are focused on probiotics' anticancer immunity in specific cancers such as, skin cancer, stomach cancer, breast cancer, lung cancer, head and neck cancer, liver cancer, cervical and colon cancer. Key features - Gives a new dimensions and insight in the role of probiotics in anticancer immunity towards various human cancers - Provides several color figures and tables to clearly explain relevant information - Includes recent information with new insights and references - Meets the needs of basic (pre-clinical) and advanced clinical researchers and postgraduate scholars

COVID-19 has spread like wildfire across the globe since the start of the SARS-CoV-2 outbreak, hampering quality of life at multiple levels and causing many deaths. Many aspects of the human experience have been affected, with a body of research being published on its effects on psychological and physical well being, loss of jobs, pay cuts, education, and unpaid caregiving. New findings on these aspects are still emerging as we learn more about the consequences of the pandemic. This book is intended as a simple summary of recent findings about COVID-19 for academicians and students from science, humanities and commerce backgrounds to understand the pandemic from a microscopic view and how it has touched our lives at different levels. A collection of topics is presented and explored through chapters dedicated to niche topics on COVID-19. Each chapter is authored by expert scientists, academicians and scholars from leading institutions in India. The key features of this book set are: - Interdisciplinary content, making it useful for readers from different academic streams - A blend of basic and applied research in biology, medicine and social science - A focus on findings from India - Updated References for advanced readers This collection of topics is invaluable for researchers and working professionals in industry and academia as well as general readers who want a broad, insightful perspective on COVID-19.

Gastrointestinal cancer is one of the most prevalent causes of cancer-related deaths in the world. Recent research demonstrates that phytochemicals are critical in preventing and managing gastrointestinal cancer. The increased intake of phytochemicals could reduce the risk of cancer by inhibiting cancer cell proliferation, inducing apoptosis and autophagy, and suppressing angiogenesis as well as cancer cell metastasis. These mechanisms are also known to counter Helicobacter pylori infection and modulate gut microbiota. There is preliminary data suggesting that daily supplementation with high doses of certain vitamins combined with conventional therapeutic agents may enhance their growth inhibitory effects on tumor cells and protect normal tissues against some of their toxic effects. This book attempts to fill gaps on the role of phytonutrients in the treatment of cancer in the gastrointestinal tract (GIT). It discusses the action of individual vitamins on cellular and molecular parameters and describes how vitamins inhibit protein kinase C activity, increase the production of certain growth factors, and modulate the expression of a number of oncogenes. The book is divided into 2 parts. The first part summarizes the pathophysiology of GIT cancers and introduces readers to anticancer phytonutrients. A chapter on the status of FDA approved nutraceuticals rounds up this section. The second part of the book provides a systematic review on the different plant derived chemicals that can be used to treat GIT cancer. Each chapter in this section focuses on a specific type of phytochemical agent and its molecular mechanisms relevant to the disease. This book will give the reader a holistic view of gastrointestinal cancer treatment and the value of natural compounds in developing functional food and drugs for preventive medicine.