Current Chinese Science

ISSN (Print): 2210-2981
ISSN (Online): 2210-2914

Volume 2, Issue 6, 2022

This journal supports open access

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About The Section


Publishes original research articles, letters, case reports, reviews/mini-reviews and guest edited thematic issues on various topics related to bioinformatics. Articles may be focused largely, but not exclusively, on contributions from China.

The Bioinformatics section of the journal Current Chinese Science publishes original research articles, letters, case reports, reviews/mini-reviews and guest edited thematic issues on various topics related to bioinformatics. Articles may be focused largely, but not exclusively, on contributions from China.

This section is not limited to a specific aspect of the field but is instead devoted to a wide range of sub fields in the area. Articles of interdisciplinary nature are particularly welcome. This section focuses on advances in artificial intelligence (AI) and big data in biology/medicine and computational molecular/structural biology, encompassing areas such as AI in precision medicine, computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Developments in these fields have direct implications on key issues related to health care, medicine, genetic disorders, development of agricultural products, renewable energy, environmental protection, etc.

Editors bioinfo_Dongqing-Wei-sh_001 Wei Dongqing Shanghai Jiaotong University Shanghai China

Dr. Dong-Qing Wei is a Professor of Bioinformatics at the Department of Bioinformatics and Biostatistics, College of Life Science, Shanghai Jiaotong University, China. He received his PhD degree in 1987 from the University of Puerto Rico. Over the past three decades he has made many grand breaking contributions to the development of bioinformatics techniques and their interdisciplinary applications to systems of ever-increasing complexity. Prof. Wei has published more than 300 journal papers, 9 monographs with around 7000 SCI citations. He was invited to give invited and plenary talks in more than 100 conferences, he also organized 10 international conferences, for example, Theory and Computational Chemistry (ACC2008), AI and Precision Medicine (2017-2018) and International Conference on Computational and System Biology (ICCSB)(2009-2015), among others. Dr. Dong-Qing does research in Bioinformatics and Biostatistics, protein-protein interactions and networks, molecular machines, proteins-drug interactions and drug designs, membrane protein dynamics, deep learning and precise medicine, CYP450 and personalized medicine.

魏冬青 男,1962年生,长聘教授,博士生导师。就职于上海交通大学生命学 院及微生物代谢国家重点实验室,Nature-Springer期刊“Interdisciplinary Sciences-Computational Life Sciences”主编(科学院2区)。长期从事生物信息 学,生物体系的分子模拟,药物代谢与个性化药物, 疾病与生物标志的精准模 型,计算机辅助药物设计,蛋白质相互作用与识别, 蛋白机器等领域的研究工 作。主持国家重点研究领域项目,自然科学基金重点项目和多项国家自然科学 基金面上项目。发表SCI文章400篇,主编专著9部,引用超过9000次,H因子 55。中国交叉科学学会副理事长,中国卫生信息学会大数据应用评估与保障专 业委员会副主委,中国运筹学会计算系统生物学常务理事。获得横山亮次奖、 中华医学二等奖、计算机协会自然科学二等奖,上海市科学技术一等奖和上海 市优博导师称号。
Section Editors Genetics bioinfo_william-ccs-as_001 William C.C.S. Queen Elizabeth Hospital Kowloon Hong Kong

Dr William Cho is a Chartered Scientist (UK), Registered Chinese Medicine Practitioner, and Fellow Member of several institutes, including the Institute of Biomedical Science (UK), Hong Kong Institute of Biomedical Science and Hong Kong Society for Molecular Diagnostic Sciences. Dr Cho devotes in cancer research in the aspects of cancer biomarkers, non-coding RNA, genomics, proteomics, next-generation sequencing, bioinformatics as well as evidence- based Chinese medicine, diabetes, meta-analysis, etc. Dr Cho has published about 300 SCI peer-reviewed papers with a total citations about 10,000 times, e.g. Lancet Oncology, Nature Communications, PNAS, Journal of Extracellular Vesicles, Clinical Cancer Research, Clinical Chemistry, Annals of Oncology, Theranostics; over dozen of books including "MicroRNAs in cancer translational research", "An omics perspective on cancer research", "Supportive cancer care with Chinese medicine", and over two dozen of book chapters.
Proteomics bioinfo_william-ccs-as_001 Khanh Le Nguyen Q. College of Medicine Taipei Medical University Taipei Taiwan 0000-0003-4896-7926 57208281644

Le Nguyen Quoc Khanh is an Assistant Professor with the College of Medicine, Taipei Medical University (TMU), Taiwan. Prior to joining TMU, he was a Research Fellow at the School of Humanities, Nanyang Technological University (NTU), Singapore. His research interests are to apply AI (machine learning, deep learning, and natural language processing) in multidisciplinary studies, especially Bioinformatics, Computational Biology, Biomedical Informatics, and Radiomics.
Metagenomics data Mining bioinfo_-ccs-as_001 Ning Kang Huazhong University of Science and Technology School of Life Science and Technology Beijing China

Kang Ning, Professor, PI of Microbial Bioinformatics Group and Director of Department of Bioinformatics and Systems Biology, School of Life Science and Technology, Huazhong University of Science and Technology.

Prof. Kang obtained his BS in Computer Science from USTC, and PhD in Bioinformatics from NUS. He obtained his Post-Doc training in Bioinformatics from the University of Michigan. Besides, Kang has more than 20 years of experience in bioinformatics for omics big-data integration, microbiome analyses and single-cell analyses. His current research interests include AI methods for multi-omics, especially metagenomics data mining, as well as their applications. He is also interested in synthetic biology and high- performance-computation.

Kang is the leading or corresponding author of over 100 papers and reviews on leading journals including PNAS, Gut, Genome Biology, Nucleic Acids Research, Briefings in Bioinformatics and Bioinformatics, which have more than 3,000 citations. He has been the committee member of several national bioinformatics and biology big-data committees in China. He serves as an editorial board member of the journal Genomics Proteomics and Bioinformatics, and Scientific Reports, and served as reviewers for several international funding agencies including UK-BBSRC and UK- NERC.

Editorial Board Members bioinfo_ebm_Zhao-qi-sh_001 Zhao Qi University of Science and Technology Liaoning Anshan China

Dr. Qi Zhao received his Bachelor degree and PhD from Wuhan University and Chinese Academy of Sciences in 2005 and 2011, respectively. Since 2011, he has been a faculty member as a lecturer and associate professor in Liaoning University, China. Now he is a full professor in the University of Science and Technology Liaoning, China. His research interests include bioinformatics, big data, machine learning and network analysis. Dr. Zhao has been a part of several well-known research journals including Scientific Reports, PLOS ONE, Frontiers in Genetics and many more and has published 56 SCI journal papers in the fields of bioinformatics.
bioinfo_ebm_Wenzheng-sh_001 Bao Wenzheng School of information and electrical engineering Xuzhou University of Technology Xuzhou China

Dr. Wenzheng Bao received his master degree in computer science from the University of Jinan in 2015 and Ph.D in the same discipline from Tongji University in 2018. He currently works at the school of information and electrical engineering, Xuzhou University of Technology, Xuzhou, China. His research interests include bioinformatics, machine learning, computational biology and proteomics. He has served as a reviewer for multiple well-renowned journals including Neurocomputing, Neural Network, Oncotarget, Plos One etc.
bioinfo_ebm_Chuan-Le-sh_001 Xiao Chuan-Le Zhongshan Ophthalmic Center Sun Yat-sen University Guangdong China

Chuan-Le Xiao obtained a doctorate (Ph.D.) in Bioinformatics from Hunan Agricultural University, China. Currently he is a principal investigator at State Key Laboratory of Ophthalmology, Zhongshan Ophthalmology Center of Sun Yat-sen University. He dedicated to studying the computational algorithms and application in the field of high-throughput sequencing and has developed a series of widely used software to solve the computational problems in the three-generation sequencing studies. He authored more than 40 publications in peer-reviewed journals, including several high impact journals, such as Nature Methods, Molecular Cell, Nature Communications.
bioinfo_ebm_Wang-Hong-sh_001 Wang Hong School of Information Science and Engineering Shandong Normal University Jinan China

Dr. Wang serves as a Professor, Doctoral Supervisor and Dean of School of Information Science and Engineering, Shandong Normal University. Dr.Wang obtained a PHD degree in 2002 from the Computing Institute of the Chinese Academy, BA and MA degree in 1984 and 1991 from Tianjin University, under the supervision of Prof. Zhongshan Wei. Dr. Wang then joined Shandong Normal University in February (1991), where served as a Postdoctoral Researcher at the Postdoctoral Station in 2009. Current research interests include machine learning, data mining, bioinformatics and social computing.
ccs_ebm_Yadav-dk-sh_001 Yadav D.K. College of Pharmacy Gachon University of Medicine and Science Incheon South Korea 0000-0003-1102-1993 36997636500 L-1846-2015

Dr. Dharmendra Kumar Yadav completed his Ph.D in Biological Science from CSIR-Central Institute of Medicinal and Aromatic Plants Lucknow India, postdoctoral studies from Hanyang University, Korea and University of Delhi, India. Presently, he is working as an Assistant Professor and a Principal Investigator for NRF project (Korea Government) in College of Pharmacy at Gachon University Korea. He received the Young Scientist award from the Science and Engineering Research Board, New Delhi in 2014. Dr. Yadav has published more than 70 papers in reputed journals, 03 Book Chapters and a Patent. His research interests are in atomic level molecular simulation of Plasma Medicine, Computer-Aided Drug Design and Molecular Modelling of Biological networks etc. He is also a member of several scientific societies and academic bodies.
ccs_ebm_Liang-c-sh_001 Liang C. School of Information Science and Engineering Shandong Normal University Jinan China 0000-0003-3832-0969

Dr. Liang is currently an Associate Professor at the School of Information Science and Engineering, Shandong Normal University. She received her MD and PhD degrees in 2010 and 2015 from Hunan University. From 2012 to 2014, she studied at Donnelly Centre, University of Toronto and was also awarded an Excellent Doctoral Dissertation of Hunan University in 2016. Her current research interests include bioinformatics and machine learning.
ccs_ebm_Wang-Bing-sh_001 Wang B. Anhui University of Technology Ma'anshan China 000-0003-4945-7725

Dr. Bing Wang received the B.S. degree from Hefei University of Technology in 1998 and the Ph.D. degree from University of Science and Technology of China in 2006, respectively. He is a full professor and Dean in the School of Electrical and Information Engineering, Anhui University of Technology, China. His research interests mainly focus on Bioinformatics, computer vision, machine learning, and Chemo informatics, with more than 140 journals and conferences papers and H-index of 23. He is a senior member of IEEE from 2014.
ccs_ebm_j-Tan-sh_001 Tan J. Beijing University of Technology Beijing China

Dr. Jianjun Tan is a Professor of Bioinformatics at the Faculty of Environment and Life in Beijing University of Technology. His group has got and completed more than 17 scientific research projects, including the National Key Basic Research Program of China, Chinese Natural Science Foundation project and others, in which 1 project is underway. He accumulated abundant experience in molecular design and drug design. He has published more than 100 papers.
ccs_ebm_Li-Hongdong-sh_001 Li H. Central South University Changsha China

Hongdong Li is an Associate Professor (tenure track) in School of Computer Science and Engineering, Central South University. He received the Bachelor (Pharmaceutical Engineering) and PhD (Analytical Chemistry) degree from College of Chemistry and Chemical Engineering, Central South University, Changsha, P.R. China in 2007 and 2012, respectively. He did postdoctoral training in computational medicine in University of Michigan, Ann Arbor. Then he joined Institute for Systems Biology (Seattle) as a Research Scientist studying systems biology of diseases. His interest include bioinformatics, functional genomics and machine learning.
ccs_ebm_Zhu-f-sh_001 Zhu F. Zhejiang University Hangzhou China ccs_ebm_Samal-sh_001 Samal B.B. National Institute of Mental Health Bethesda MD USA 57198168797 ccs_ebm_park_001 Park S. Yeungnam University Gyeongsan South Korea bioinfo_zhu-h-as_001 Zhu H. Peking University Beijing China

Prof. Huaiqiu Zhu is a tenured professor at the Department of Biomedical Engineering, Peking University. His research interests include bioinformatics methods based on genomic sequences, protein sequences and structures. Dr. Zhu's lab has addressed the bioinformatics methods of genome analysis and annotation, and developed a series of methods of microbial gene prediction, genome comparison, and protein molecular dynamics. His lab now focuses on metagenomics issues driven by human health and environments, and data mining in medicine informatics. He has developed tools such as sequence assembly, gene prediction and microbial community comparison for metagenomic sequences produced by NGS.
bioinfo_li-md-as_001 Li M.D. Zhejiang University Hangzhou China

Professor Ming Li has studied genetics and molecular biology of human diseases, specifically addictive disorders for more than 20 years. During those years, Dr. Li has published more than 200 peer-reviewed publications and has trained approximately 70 graduate students and postdoctoral fellows. His publications are very diverse, ranging from molecular pharmacology, neuropsychopharmacology, molecular biology, statistical genetics, computational biology, to bioinformatics. Dr. Li has served as a regular and ad-hoc member of many study panels and sections in the US and other countries. In addition, he has served as an advisor for a dozen research centers/programs and ad-hoc reviewers or board members for more than 30 scientific journals. He has been invited to give more than 100 seminars or oral presentations by various national and international conferences and institutions throughout the world.
bioinfo_shoenfeld-y-as_001 Shoenfeld Y. Tel Aviv University Tel Aviv Israel

Professor Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center, which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Professor Shoenfeld is also the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at Tel-Aviv University. Professor Shoenfeld’s clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 2000 papers in journals. Professor Shoenfeld is on the editorial boards of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of Autoimmunity Reviews (Elsevier) (Impact factor 8.9) and co-Editor of the Journal of Autoimmunity (Impact factor 8). For the past twenty years Yehuda has been the Editor of “Harefuah” – The Israel journal in medicine (Hebrew). He was recently awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.In 2018 he was elected to the Israeli Academy of Sciences.
bioinfo_khan-a-as_001 Khan A. University of Nizwa Nizwa Oman

Dr. Khan received his B.Sc degree from the University of Malakand and M.Sc degree in distinction from the University of Peshawar, Pakistan. In 2007 Dr. Khan got scholarship from HEJ Research Institute of Chemistry for Ph.D. and completed his Ph.D. in the field of enzymology in 2013. During his PhD, he received split PhD scholarship from OAED Austria, and worked as visiting scientist in University of Innsbruck, under the supervision of Univ.-Prof. Dr. DDDDr. h.c. Bernd Michael Rode (Institute of General, Inorganic and Theoretical Chemistry University of Innsbruck, Austria). Dr. Khan has expertise in Medicinal Chemistry, enzyme inhibition, Enzyme kinetics studies, STD NMR studies for protein-ligand interaction and Computational Chemistry. He has published more than 200 articles in international peer review journals with impact factor of more than 450 and citation more than 2000. Beside this, he has four US patents, two of them published and the other two are filed up. He got five times Research Productivity Award from Pakistan Council of Science and Technology and two time best poster award in international symposiums.
bioinfo_zhang-ym-as_001 Zhang Y-M. Huazhong Agricultural University Wuhan China

Yuan-Ming Zhang is a quantitative geneticist. He obtained his PhD from Nanjing Agricultural University in 2001. He worked at Southwest University, Rongchang (1986-1999) and Nanjing Agricultural University (1999-2014), and moved to Crop Information Center of Huazhong Agricultural University in 2014. He did his postdoctoral research at the University of California, Riverside during 2003-2005. His current interests are in the development and application of statistical approaches to mine novel genes of complex traits, e.g., multi-locus GWAS (mrMLM) and QTL mapping (GCIM) methodologies, crop genome variants and complex trait, linkage map construction, and mixed major-genes plus polygenes inheritance. He is also the Associate Editor of Heredity.
bioinfo_kamaraj-b-as_001 Kamaraj B. Imam Abdulrahman Bin Faisal University Al Jubail Saudia Arabia

Dr. Balu Kamaraj is an Assistant Professor at Imam Abdulrahman Bin Faisal University (CAMSJ), Saudi Arabia. Previously, he served as a Scientific Manager at Excelra Knowledge solution, India, and post-doctoral researcher at the University of Antwerp, Belgium. Also, Dr. Kamaraj served as a visiting postdoctoral researcher at the University of the Basque Country, San Sebastian, Spain. Dr. Balu Kamaraj has nearly 7 years of experience in academic and industrial research in the area of computational structural biology. His scientific interests focus on a range of issues related to structural Bioinformatics. By adopting the multidisciplinary approach to the analysis of biological systems such as 3-D Modelling of protein structures, protein-ligand complex, protein-protein complex, and protein-DNA complex. He would like to observe how certain mutations alter the dynamic behavior of proteins and their interaction with other molecules. He is very much interested in molecular folding, evolution, and binding interactions, and structure/function relationships of experimentally solved structures and from computational models. Notably, Dr. Balu Kamaraj has published several original, review articles and book chapters, including the first and corresponding author.
bioinfo_abdullah-sna-as_001 Abdullah S.N.A. Universiti Putra Malaysia Selangor Malaysia

Dr. Siti Nor Akmar Abdullah is a Professor in Plant Molecular Biology in Universiti Putra Malaysia (UPM). Her research focuses on plant functional genomics, genetic manipulation and biomarker technology. She served as the Director of the Institute of Plantation Studies (2016 – 2019) and Head of Laboratory of Plantation Crops (2007-2016) in UPM. She led several research projects at the national level and secured research grants from industry members. To date she has published about 100 papers. Her publications can be found in top ranking journals including Plant Biotechnology Journal, BMC Plant Biology, Planta, Plant Cell Reports and Plant Physiology and Biochemistry.
bioinfo_sakkiah-as_001 Sakkiah S.D. National Center for Toxicological Research (NCTR) Little Rock AR USA

Dr. Suguna Devi Sakkiah currently works as a staff fellow at the National Center for Toxicological Research, USA. She received her Ph.D. from Gyeongsang National University, South Korea and her master’s degree from Bharathiar University, India. In 2010, she received a Young Pioneer Research Scientist award while pursuing her Ph.D. After receiving her Ph.D., she worked as a postdoctoral researcher at Gwangju Institute of Science and Technology, the University of California, Los Angeles and the Cedars-Sinai Medical Center, Los Angeles. During her research career, Dr. Sakkiah has published more than 60 peer-reviewed research articles and review papers, and two book chapters.
bioinfo_J-Meng-as_001 Meng J. Dalian University of Technology Dalian China

Dr. Jun Meng is currently a professor at the School of Computer Science and Technology, Dalian University of Technology. She received the PhD degree from the Dalian University of Technology in 2012. Her research interests include data mining, machine learning, and bioinformatics. She has published more than 100 research papers in various journals and conferences. Her research projects are funded by the National Natural Science Foundation of China.
bioinfo_M-Qasim-as_001 Qasim M. Kohat University of Science and Technology Kohat Pakistan bioinfo_h-Cai-sh_001 Cai H. South China University of Technology Guangzhou China

Dr. Hongmin Cai has received a Bachelor's and Master's degree from Harbin Institute of Technology in 2001 and 2003, respectively. He got Ph.D from University of Hong Kong in 2007. He has been a visiting research fellow at the Center of Bioinformatics at Harvard University, and Section for Biomedical Analysis at the University of Pennsylvania. He was a visiting Professor at the Hong Kong Baptist University and Kyoto University. In 2012, he was associate Professor of School of Computer Science and Technology, South China University of Technology. In 2014, he was awarded Outstanding Youth Teacher in Guangdong Province. He was promoted to full professor in 2016. He was Guest Professor at Kyoto University. He has principled and co-principled more than 10 fundings from National Natural Science Foundation of China (NSFC), Guangdong Province and other sources. He has published around 60 papers in top journals and conferences. His research interests include biomedical image processing and bioinformatics, in particular omics data integration and radiomics for precision medicine.
bioinfo_rehan-m-as_001 Rehan M. King Abdulaziz University Jeddah Saudi Arabia bioinfo_liu-x-as_001 Liu X. Shandong University Weihai China

Dr. Xiaoping Liu is currently a Professor at the School of Mathematics and Statistics, Shandong University, China. He completed his PhD in Informatics and Systems Biology, from the Institute of Systems Biology, Shanghai University in 2012. His research interests mainly focus on Computational biology, Bioinformatics, System biology, Machine learning. He has more than 30 articles published in reputed journals.
bioinfo_w-Zhang-sh_001 Zhang W. Huazhong Agricultural University Wuhan China

Dr. Wen Zhang obtained the Bachelor's degree and the Masters degree in Computational Mathematics from Wuhan University in 2003, 2006, and got the doctoral degree in computer science from Wuhan University in 2009. He has worked at Wuhan University from 2009 to 2018. He is currently a Professor at College of Informatics,Huazhong Agricultural University, People’s Republic of China. His research interests include machine learning, data mining and bioinformatics. He has published more than 60 papers on reputed journals or conferences, such as Nucleic acids research, Bioinformatics, PLos Computational biology, IEEE/ACM transactions on computational biology and bioinformatics, Information Science,etc.
bioinfo_niu-b-as_001 Niu B. Chinese Academy of Sciences Beijing China

Dr Beifang Niu received his PhD in Computer Software and Theory from the Super Computing Center, Chinese Academy of Sciences, Beijing, China. Currently, he is a Research Professor at the Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. He is interested in developing high-performance bioinformatics and computational biology methods and applying them in cancer genomics and metagenomics to help understand the origins and progression of cancer. He has more than 15 years of experiences in bioinformatics, genomics and computational biology. He has contributed his valuable publications in different scientific journals.
bioinfo_wadood-a-as_001 Wadood A. Abdul Wali Khan University Mardan Pakistan

Dr. Abdul Wadood is currently a Tenured Associate Professor at the department of Biochemistry, Abdul Wali Khan University Mardan, Pakistan. He received his PhD degree from HEJ Research Institute of Chemistry, University of Karachi, Pakistan in 2010. His research interest includes molecular modelling, computational medicinal chemistry, bioinformatics and machine learning. He has published more than 200 research articles in various prestigious journals.
bioinfo_yu-zg-as_001 Yu Z-G. Xiangtan University Hunan China

Prof. Zu-Guo Yu received his Ph.D. degree in mathematics from Fudan University, Shanghai, China, in 1997. He is currently a distinguished professor at Xiangtan University and an adjunct professor at Queensland University of Technology. His research interests include fractals, complex network analysis, biological and environmental data processing. He has published more than 120 research papers in journals including Mol. Biol. Evol., Bioinformatics, Mol. Ecol. Res., Environ. Modell. Softw., Mol. Phylogenet. Evol., Scientific Reports, BMC Evol. Biol., BMC Bioinformatics, Fuzzy Sets and Systems, J. Chem. Phys., Phys. Rev. E, J. Stat. Mech., Chaos, J. Geophys. Res.

bioinfo_Huang-j-as_001 Chen Peng Institute of Physical Science and Information Technology Anhui University Hefei China

Dr. Peng Chen is currently a Professor at the School of Internet; Institutes of Physical Science and Information Technology, Anhui University, and Adjunct Professor at the Hefei Institute of Intelligent Machine, Chinese Academy Sciences. His research interests include data mining with applications to bioinformatics and computer vision, etc. He has published more than 100 high quality referred papers in conferences and journals.
bioinfo_Aung-lhh-as_001 Aung L.H.H. Qingdao University Qingdao China

Dr. Lynn Htet Htet Aung received her MD-PhD in Cardiology from Guangxi Medical University and Master degree in Bioinformatics from the University of Illinois at Chicago. She is currently the director of the Center for Molecular Genetics, Institute for Translational Medicine, Qingdao University. She has published 46 SCI papers in the field of population genetics, apoptosis, mitochondrial dynamics, cardiovascular disease, and cancer. Her research interests are genetics, epigenetics, oxigenetics, and aging.
Associate Editorial Board Members bioinfo_Jumei-Zeng-ab_001 Zeng Jumei West China School of Public Health West China Teaching Hospital Sichuan University Sichuan China

Dr. Jumei Zeng received her Ph.D. in Molecular Microbiology from Huazhong Agricultural University, Wuhan, China. Currently, she is serving as an Associate Professor at West China School of Public Health, West China Teaching Hospital, Sichuan University, Sichuan, China. Her research interests include Microbial genomics, genetics and physiology, mycobacterium, antibiotic resistance, tuberculosis, microbial pathogenesis, transcriptional regulation, phosphorylation modification. She has published over 37 research articles. Dr. Zeng has received several awards including Scientific research achievements award, Sichuan Provincial High-level Overseas Talents etc.

bioinfo_Lihong-Peng-sh_001 Peng Lihong School of Computer Science Hunan University of Technology Hunan China 0000-0002-2321-3901

Lihong Peng received M.S. degree from the School of Computer and Communication, Hunan University, China, in 2008, and a PhD degree from the College of Information Science and Engineering, Hunan University, China. She is working in Hunan University of Technology as an associate professor. Her research interests include Bioinformatics, Machine Learning, and Data Mining.
bioinfo_Zhang-hy-sh_001 Zhang H.-Y. Huazhong Agricultural University Wuhan China

Hong-Yu Zhang is currently a professor and Dean of College of Informatics in Huazhong Agricultural University. He completed his Ph.D. in biophysics at the Institute of Biophysics, Chinese Academy of Sciences in 1997. His research interest focuses on the origin and evolution of life and systems biology-based drug discovery. Dr. Zhang has published 200+ articles in the fields of systems chemistry and systems biology. He received Servier Young Investigator Prize from Chinese Pharmacological Society in 1999, Young Investigator Prize in Chemistry from Chinese Chemical Society in 2005 and Prize for Natural Science Research in 2011 from Ministry of Education, China.
bioinfo_Shi-ting-sh_001 Shi Ting Department of Bioinformatics and Biostatistics Shanghai Jiao Tong University Shanghai China 0000-0003-3921-4412

Ting Shi received her BSc in chemistry from Northwest University. During her PhD study in Northwest University, she spent one year in Lab of Computational Chemistry and Drug Design, School of Chemical Biology & Biotechnology, Peking University Shenzhen Graduate School. Then she worked as a postdoctoral Research Associate at Chinese Academy of Sciences Shanghai Institute of Materia Medica. In 2010, she began her academic career as a research associate at the School of Medicine, Shanghai Jiao Tong University. Three years later, she joined in School of Life Sciences & Biotechnology, and was appointed as associate Professor in 2014. Now her interests include computational biology, enzyme mechanism, rational design of enzyme, protein structure/function, structure-based drug design, antibiotics.
bioinfo_mahapatra-dk-as_001 Mahapatra D.K. Rashtrasant Tukadoji Maharaj Nagpur University Nagpur India

Dr. Debarshi Kar Mahapatra is currently an Assistant Professor at the Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India. His research interests include computer assisted rational designing, synthesis of low molecular weight ligands against druggable targets, development of drug delivery systems, and optimization of unconventional formulations. He has made several publications in various reputed international journals and presented his original contributions at several international platforms for which he also received awards. He has contributed several edited books, syllabus-based textbooks, lab manuals, book chapters, magazine articles, and guide books on Pharmaceutical Chemistry, Natural Products, Pharmacology, and Pharmaceutics. He also serves a reviewer and an editorial board member for several journals of international repute. He is an active member of several professional and international scientific societies.
bioinfo_Das-rk-as_001 Das R.K. University of North Bengal Darjeeling India

Dr. Rajesh Kumar Das is currently the Faculty of Chemistry, University of North Bengal, India. He did his M.Sc. form NBU with distinction and awarded a University Medal. He completed the Ph.D on Solution Thermodynamics and post doctorate on Bioinformatics. His current research interests include Computer Aided Drug Design, QSAR, Bioinformatics, Cheminformatics, Computational Chemistry. He has authored or co-authored over 20 articles in peer review journals. Dr. Das is a life member of Chemical CRSI, Indian Chemical Society, Indian Science Congress. He is currently the Guest Editor of The Open Microbiology Journal, Editorial Board Member of Journal of Drug Design and Medicinal Chemistry, Reviewer of Drug Development Research, and International Journal of Environmental & Analytical Chemistry , and Bentham Brand Ambassador of Bentham Science.
bioinfo_zhou-p-as_001 Zhou P. Shanghai Jiao Tong University Shanghai China

Dr. Zhou received his PhD degree in China Agricultural University in 2007. Since 2011, he joined Shanghai Jiaotong University as an Assistant Professor and promoted to be Associate Professor in 2014. Dr. Zhou mainly focuses on forage and turf grass abiotic stress molecular physiology. He is studying the roles of plant hormones and stress proteins in forage and turf grass under abiotic stress. To present, Dr. Zhou has published more than 24 scientific papers in the professional journals.
bioinfo_yu-jf-as_001 Yu J-F. Dezhou University Dezhou China

Dr. Jia-Feng Yu is a Professor in the Institute of Biophysics, Dezhou University, China. He received his PHD degree in Bioinformatics from Southeast University in 2012, and he is currently deputy director of Shandong Key Laboratory of Biophysics. His research field involves prokaryotic genome annotation, intrinsically disordered proteins, flora, lncRNA, small open reading frames, some works have been published in NAR, DNA Res, CMLS, BMC Bioinformatics, etc.
bioinfo_ortega-jm-as_001 Ortega J.M. Universidade Federal de Minas Gerais Belo Horizonte Brazil

Dr. Ortega holds a degree in Biosciences and Ph.D. in Biochemistry from the University of Sao Paulo. He is currently an associate professor at Federal University of Minas Gerais, leading the Biodata Lab. He has experience in Biochemistry, with emphasis on bioinformatics, acting on the following topics: chromatin structure, yeast two-hybrid system, biochemistry of transcription factors and bioinformatics. Participated twice in the board of the Brazilian Association of Bioinformatics and Computational Biology and was the organizer of the X-meeting 2005. Participates in the PhD program on Bioinformatics at UFMG and Minas Gerais Genome Network and is responsible for the Center for High-Performance Computing at ICB/UFMG.
bioinfo_wu-b-as_001 Wu B. Shantou University Medical College Shantou China

Dr. Bingli Wu's main research interest is the application of both molecular experiments and bioinformatics, using of the biological data (microarray and RNA-seq) from our research group and public database, to analyze the biological functions, expression and regulation mechanisms, and cell signaling pathways of genes involved in the proliferation, invasion and metastasis of esophageal cancer and brain tumor.
bioinfo_krishnasamy-g-as_001 Krishnasamy G. University of Turku Turku Finland

Dr. Gopinath Krishnasamy is currently working as a Senior Researcher at the Institute of Biomedicine, University of Turku, Finland. He has obtained his doctoral degree in Bioinformatics from Alagappa University, Karaikudi, India in 2016. Then, he worked as Researcher and Postdoctoral researcher at the Department of Chemical Engineering, Konkuk University, Seoul, South Korea (Jan 2016 to May 2019). His research areas are Computational Enzyme Engineering, Computer Aided Drug Designing and Natural products research, Molecular dynamics, Database development working interdisciplinary projects (Enzyme engineering, computational approaches in Drug designing and natural product research.
bioinfo_sweidan-k-as_001 Sweidan K. The University of Jordan Amman Jordan bioinfo_li-j-as_001 Li J. Fuzhou University Fuzhou China

Dr. Jinyu Li obtained his PhD in Computational Biology at RWTH-Aachen University, Germany in 2015, supervised by Prof. Paolo Carloni. He then worked as a postdoc at Forschungszentrum Jülich, Germany. Starting from 2016, he established his own lab at Fuzhou University, China and has been a full professor in chemistry since 2017. His research interests mainly focus on the development of in silico methods and their integrations with biological experiments for biomedicine. He is a fellow member of the Youth Committee of the Chinese Anti-Cancer Association. He was awarded the Minjiang Scholar Professorship in 2015, and the Distinguished Young Scholar of the Natural Science Foundation of Fujian in 2019. He has published over 40 papers on peer-reviewed journals, e.g. Nat Chem Biol, JACS, Angew, J Med Chem, and PLoS Comput Biol.
bioinfo_pal-k-as_001 Pal K. University Federal Rio de Janeiro Rio de Janeiro Brazil

Prof. (Dr.) Kaushik Pal belongs to an Indian citizen and born in Kolkata. Currently acting as “Visiting Research Professor” at Federal University of Rio de Janeiro, Brazil and acting as Distinguished Chair Professor and Group Leader (Chief-Scientist & Faculty Fellow) position in Wuhan University, Wuchang Dist., Hubei, Republic of China. Before, he worked as a “Visiting Professor” at IIUCN, School of Energy Materials, Mahatma Gandhi University, Kottayam, Kerala. He received his Ph.D. from University of Kalyani. Most significant prestigious awards “Marie-Curie Experienced Researcher (Postdoctoral Fellow)” offered by the European Commission in Greece and “Brain Korea (BK-21) National Research Foundation Visiting Scientist Fellowship” in South Korea achieved his research career. He was appointed “Senior Postdoctoral Fellow” in China and within a year achieved a prestigious position “Chief-Scientist & Faculty (CAS) Fellow” by Chinese Academy of Science. He also served as “Research Professor (Group Leader & Independent Scientist)”, at Bharath University (BIHER), Research & Development, Chennai. His current spans are focusing e.g. Nanofabrication, functional Materials, condensed matter physics (Expt.), CNTs/graphene, liquid crystal, polymeric nanocomposite, switchable device, electron microscopy and spectroscopy, bio-inspired materials, drug delivery, tissue engineering, cell culture and integration, switchable device modulation, flexible and transparent electrodes, supercapacitor, optoelectronics, green chemistry, and biosensor applications. His outstanding research finding and novelty published around 65-articles in several international top-tier journals likewise: IOP Nanotechnology, Royal Chemical Society, Elsevier, Springer, IEEE publications got the highest citation in every year and performed editing 20- book’s chapters and 8-Review Articles. Throughout his academic experiences, skills and research background deserve him as an Editorial member of ‘World Journal of Nanoscience and Nanotechnology’, ‘Current Graphene Science’, ‘J. of Chemical Reviews’, ‘Pan Stanford', ‘En Press’, and ‘InTech Open Access’ publisher edited several book’s chapters and since last year reviewed around 150 articles.
bioinfo_Wang-x-as_001 Wang X. Henan Institute of Technology Xinxiang China

Dr. Xianfang Wang is currently a professor and an academic leader at Henan Institute of Technology, China. She received her PhD degree in 2009 from Jiangnan University, Wuxi, China. Her research interests focus on Artificial Intelligence, Machine Learning, Data Mining, Bioinformatics and Computational Biology. She has published more than 60 peer-reviewed journal papers, conference proceedings. She has also published 2 books with co-authors. Recently, Dr. Wang works in Graph Convolutional Networks, DTA Prediction and Drug Repositioning. She has finished over 5 research fundings from the National Natural Science Foundation of China (NSFC), the Support Program for Innovative Talents in Universities of Henan Province, the Research Project of Science and Technology in Henan Province and the Henan Natural Science Foundation.
bioinfo_Muthusamy-k-as_001 Muthusamy K. Alagappa University Karaikudi India

Dr Karthikeyan Muthusamy is an Assistant Professor at the Department of Bioinformatics, Alagappa University, Karaikudi, India. He received his Masters and a PhD degree in Biomedical Genetics from the Department of Genetics, Dr ALMPGIBMS, University of Madras, Chennai, India. He has been actively researching in understanding the genetics and molecular basis of variation in drug response, drug Repurposing for human diseases like hypertension, diabetics, cardiovascular diseases, renal failure viral diseases, and so on to study therapeutic efficacies and side effects of the drugs through the computational and experimental methods. In connection with that, he has published more than 85 articles in peer-reviewed journals and is also an Editor in various Journals.
bioinfo_Selvaraj-c-as_001 Selvaraj C. Alagappa University Karaikudi India

Dr Chandrabose Selvaraj is a Bioinformatician with expertise in microbial informatics. He is a senior researcher in the Department of Bioinformatics, Alagappa University, India. His expertise also includes computational chemistry, Molecular modelling, and Drug design. Dr Selvaraj obtained his PhD in Bioinformatics (2014), from the Department of Bioinformatics, Alagappa University, India. He did his post-doctoral in International esteemed institutes that include Food and Drug Administration (USA), Central European Institute of Technology (CEITEC-Brno), Konkuk University (South Korea), Indian Institute of Technology-Mandi (India). His work is dedicated to understanding molecular-level interactions between the Pathogen and humans for chemical biology and drug discovery to applying theoretical and biophysical methods using various Bioinformatics approaches along with few experimental validations.
bioinfo_Wei-y-as_001 Wei Y. Chinese Academy of Sciences Shenzhen China

Dr Yanjie Wei is a Professor and the Executive Director at the Center for High-Performance Computing, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. He earned his PhD in 2007 at Michigan Tech University in the field of Computational Biophysics. From 2008 to 2011, he worked as a Postdoctoral Research Associate at Princeton University. His research focuses on high-performance computing and computational biology/bioinformatics. He has published about 60 publications in journals/conferences including Proteins, BMC Bioinformatics, PloS Computational Biology, J. of Physical Chemistry B, Cell Research, PPoPP2015, ICPP2016, etc.
bioinfo_zhang-w-as_001 Zhang W. Chinese Academy of Sciences Beijing China

Dr. Weilin Zhang received a PhD in Biomedical Engineering from the School of Biological Science and Medical Engineering, Beijing University of Aeronautics and Astronautics, Beijing, China. Currently, he is an Assistant Professor at the State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China. He received several awards such as Academic Innovation Award of Ministry of Education (2010), Travel Awards (52ed ASH Annual Meeting, America, 2010), and Excellent university graduates of Henan Province (Henan Provincial People’s Government, 2004). Besides, he is an editorial board member of the Exploratory Research and Hypothesis in Medicine and is also a member of the Chinese Society for Cell Biology. Moreover, Dr. Zhang has contributed his valuable publications in different scientific journals.
bioinfo_S-M-Bakhtiar-as_001 Bakhtiar S-M. Capital University of Science and Technology Islamabad Pakistan

Dr Syeda Marriam Bakhtiar has completed her MS in Biochemistry and Molecular Genetics and PhD in Human Molecular Genetics with a special focus on learning disabilities. Her research interests include the molecular understanding of inherited diseases/disorders and other infectious diseases more prevalent in Pakistan. She is implementing integrated Molecular Genetics and Genomics approaches to understand the complexities of the inherited genetic diseases, their characterization at the molecular level, and strategies for control and prevention. Similarly, in infectious diseases, she is particularly interested in pathogen-host interaction in analyzing the genomic data (sequencing). Her research interest also includes Bioinformatics and Computational biology approaches to analyze and interpret the vast amount of genomic data available on public databases and utilization of this data to its full potential.
bioinfo_Selvaraj-sh_001 Selvaraj G. Henan University of Technology Zhengzhou China

Dr. Gurudeeban Selvaraj is currently working as a Postdoctoral Scientist at Prof. Gilles and Prof. Wei’s lab in CERMM, Concordia University, Canada. Prior to joining CERMM, he was a postdoctoral scientist at Henan University of Technology, Annamalai University and Istanbul Medeniyet University from September 2014 to November 2017. He received his B.Sc. in Biochemistry in 2003 from Bharathiar University, and his M.Sc. and Ph.D. in Marine Biotechnology in 2008 and 2014, all from Annamalai University. He received prestigious research grants from different funding agencies includes MITACS Global link (2019), China Postdoctoral Science Foundation (2018), Henan Postdoctoral Science Foundation (2018), TUBITAK-2216, Turkey (2014), and UGC, India (2011). He published more than 50 research articles in reputed and indexed journals with total citation of 1248 and h-index of 18 since 2011.
bioinfo_lan-w-as_001 Lan W. Guangxi University Nanning China

Dr Wei Lan received his PhD in Computer Science from Central South University in 2016. Currently, he is an Assistant Professor at the Department of Computer Science, School of Computer, Electronic Information, Guangxi University, China. He has been awarded several research grants, including a National Natural Science Foundation of China Project. He has published more than 30 referred papers including Bioinformatics, IEEE/ACM Transactions on Computational Biology and Bioinformatics, Methods, Neurocomputing, IEEE Transactions on Nanobioscience. His research interests include bioinformatics, data mining, and machine learning.
bioinfo_X-Y-Wei-sh_001 Wei X-Y. Sichuan University Chengdu China

Dr. Xiao-Yong Wei is a Professor and the department head of the College of Computer Science, Sichuan University, China. He received his Ph.D in Computer Science from City University of Hong Kong and has worked as a postdoctoral fellow at the University of California, Berkeley. Xiao-Yong Wei is also affiliated with the Peng Cheng Laboratory, Shenzhen, where he works as a professor and the coordinator for the Healthism project. Healthism is an interdisciplinary project to tackle chronic diseases and significantly improve quality of life by going beyond the episodic health model developed for prevalent disease-centric-healthcare. Healthism focuses on physical and mental health to develop approaches for changing the way people adopt lifestyle for achieving best health to meet their desired goals. He has more than 20 publications
bioinfo_x-Jiang-sh_001 Jiang X. Central China Normal University Wuhan China

Dr. Xingpeng Jiang is currently a professor at the School of Computer at Central China Normal University. He is the director of the Department of Computer Science and Technology and was selected as a "Chutian Scholar-Young Scientist" in Hubei Province. He is serving as a member of the IEEE BIBM Conference Program Committee, editor of the International Journal of Data Mining and Bioinformatics, the Journal of Artificial Intelligence for Medical Sciences and the Advances in Bio-marker Science and Technology. He is also a member of the Bioinformatics Committee of the Chinese Computer Society, the member of Gene Detection Technology Branch of the Pharmaceutical Biotechnology Association and Vice Chairman of the Hubei Bioinformatics Society. His research interests include microbiome data mining and medical artificial intelligence. He has published more than 60 academic papers in the field of bioinformatics, majorly in microbiology data mining and analysis.
bioinfo_sahi-s-as_001 Sahi S. Gautam Buddha University Noida India

Section: Bioinformatics

Research Article

Identifying Native and Non-native Membrane Protein Loops by Using Stabilizing Energetic Terms of Three Popular Force Fields

Volume: 1, Issue: 1
Pp: 14-21
Author: Konda Mani Saravanan, Haiping Zhang and Yanjie Wei*
DOI: 10.2174/2665997201999200729165146
Published on: 29 July, 2020

Letter to the Editor

Computational Studies of Budesonide vs. Vilanterol: Asthma Drugs Against SARS-CoV-2 Mpro

Volume: 2, Issue: 2
Pp: 97-100
Author: Afzal Hussain* and Ashfaq Hussain
DOI: 10.2174/2210298102666220214114300
Published on: 24 March, 2022

Mini-Review Article

A Review of Nitro-Hydroxylation Transformation on Aromatic Ring

Volume: 2, Issue: 3
Pp: 189-197
Author: Jian Hang Bu, Qian-Hui Ding, Hui Zhong, Xu-Dong Zhou, Bin Li, Wei Wang* and Wen-Bing Sheng*
DOI: 10.2174/2210298102666220308155039
Published on: 27 April, 2022

Mini-Review Article

Fluorescent Pyrazole Derivatives: An Attractive Scaffold for Biological Imaging Applications

Volume: 1, Issue: 2
Pp: 197-206
Author: Alexis Tigreros and Jaime Portilla*
DOI: 10.2174/2210298101999201208211116
Published on: 08 December, 2020

Research Article

Computational Insight into the Binding Mechanism of Pyrazinoic Acid to RpsA Protein

Volume: 1, Issue: 2
Pp: 207-215
Author: Ashfaq Ur Rehman, Saadat Ali, Humaira Rafiq, Salman Rasheed, Faisal Nouroz and Abdul Wadood*
DOI: 10.2174/2210298101666210108105814
Published on: 07 January, 2021

Mini-Review Article

Application of Artificial Intelligence in Drug Repurposing: A mini-review

Volume: 1, Issue: 3
Pp: 333-345
Author: Gurudeeban Selvaraj*, Satyavani Kaliamurthi , Gilles H. Peslherbe* and Dong-Qing Wei*
DOI: 10.2174/2210298101666210204162006
Published on: 04 February, 2021

Review Article

Speciation and Infrageneric Classification in the Planktonic Dinoflagellate Tripos (Gonyaulacales, Dinophyceae)

Volume: 1, Issue: 3
Pp: 346-372
Author: Fernando Gómez*
DOI: 10.2174/2210298101999210101231020
Published on: 01 January, 2021

Research Article

In Silico Analysis of Drug Repurposing Strategy for the Identification of Potential NS3 Helicase Inhibitors Against Zika Virus

Volume: 1, Issue: 3
Pp: 373-385
Author: Lakshmanan Loganathan, S. Justin Carlus and Karthikeyan Muthusamy*
DOI: 10.2174/2210298101666210302104933
Published on: 01 March, 2021

Research Article

Identification of Stress-induced miRNAs and their Targets in Solanum lycopersicum

Volume: 1, Issue: 4
Pp: 397-405
Author: Erum Dilshad*, Zainab Nooruddin, Shadab Shaukat, Anum Munir, Syeda Marriam Bakhtiar and Hammad Ismail
DOI: 10.2174/2210298101666210617095627
Published on: 03 August, 2021

Review Article

Recent Advances in Predicting ncRNA-Protein Interactions Based on Machine Learning

Volume: 1, Issue: 5
Pp: 513-522
Author: Jingjing Wang, Yanpeng Zhao, Xiaoqian Huang, Yi Shi and Jianjun Tan*
DOI: 10.2174/2210298101666210713120933
Published on: 13 July, 2021

Research Article

Target Gene Identification and sgRNA Design for Waterlogging Tolerance in Foxtail Millet via CRISPR-Based Transcriptional Activation

Volume: 1, Issue: 5
Pp: 523-533
Author: Siti N.A. Abdullah*, Sean Mayes and Mahdi Moradpour
DOI: 10.2174/2210298101666210709104258
Published on: 08 July, 2021

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