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Article Detail:

Title:
MRI-negative medial temporal lobe epilepsy can benefit from stereotactic radiofrequency thermocoagulation applied to the amygdalohippocampal complex

Abstract:
Background: Seizure control [SC] is often poor in cases of magnetic resonance imaging-negative epilepsy after resection surgery.

Objective: This study aimed to evaluate the therapeutic efficacy of depth-electrode-guided stereotactic radiofrequency thermocoagulation [RFTC] applied to the amygdalohippocampal complex [AHC] for the treatment of patients with MRI-negative medial temporal lobe epilepsy.

Methods: A total of 62 cases with magnetic resonance imaging-negative medial temporal lobe epilepsy were retrospectively studied after the application of depth-electrode-guided RFTC to the AHC. Single-target coagulations were applied to all patients, and multi-target coagulations were applied to those patients who did not experience significant reductions in discharges after the first target ablation. Bilateral-target coagulations were applied to bilateral medial temporal lobe epilepsy patients, using single target ablation applied to each side.

Results: After 24–83 months of follow-up, 32/62 [51.61%] patients became seizure-free, and 35/62 [56.45%] patients reported significant reductions in seizure episodes. The total effective rate was 69.35% [43/62]. No significant differences were observed for SC among the single-target, multi-target and bilateral-target groups. However, a significant difference was observed for the reduction in epileptic discharges after coagulations between those patients who became seizure-free and those who did not. Magnetic resonance imaging-negative medial temporal lobe epilepsy patients can benefit from RFTC applied to the AHC. A significant reduction in epileptic discharges observed during operations after RFTC is applied may be a predictor of good SC.

Conclusion: RFTC applied to the AHC could be considered a promising method for the treatment of magnetic resonance imaging-negative medial temporal lobe epilepsy patients.

Journal Title: Current Medical Imaging

Price: $95


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