The Story of Diabetes and its Causes
Page: 1-30 (30)
Author: Ramin Malboosbaf* and Neda Hatami
DOI: 10.2174/9789815196535123010004
PDF Price: $15
Abstract
Diabetes mellitus (DM) is a complex metabolic disorder whose rising
prevalence is terrible. A deeper knowledge of the pathophysiology of diabetes could
assist in discovering possible therapeutic targets for treating diabetes and its associated
problems. The common feature of diabetes, regardless of the specific pathology
involved, is hyperglycemia brought on by the death or dysfunction of β-cell. As insulin
deficiency gets worse over time, dysglycemia progresses in a continuum. This chapter
has provided a brief review of the pathophysiology of diabetes. Also, the roles of
genetics and environmental factors have been emphasized.
Treatment Approaches and Challenges
Page: 31-56 (26)
Author: Ramin Malboosbaf* and Neda Hatami
DOI: 10.2174/9789815196535123010005
PDF Price: $15
Abstract
Diabetes drugs are given in monotherapy or in combination. The significant
challenges in effective diabetes management are optimizing current treatments to
ensure optimal and stable glucose control with minimal side effects and reducing long-term complications of diabetes. This chapter reviews these conventional drugs with
their mechanism of action, side effects, and efficacy and safety profile.
Nanomedicine for Insulin Delivery in Diabetes
Page: 57-69 (13)
Author: Morteza Rafiee-Tehrani, Somayeh Handali, Mohammad Vaziri, Sepideh Nezhadi and Farid Abedin Dorkoosh*
DOI: 10.2174/9789815196535123010006
PDF Price: $15
Abstract
Diabetes is one of the common diseases in the world and its treatment faces
challenges. Insulin is the main therapeutic agent used in the treatment of diabetic
patients. However, it has several side effects and during the day, patients may need
several insulin injections, which is not pleasant for them. Therefore, a controlled and
prolonged release system is required to decrease the injection frequency, improve the
bioavailability of insulin, and enhance the compliance of patients. Nanoparticles (NPs)
based drug delivery systems (DDSs) have been considered for insulin delivery. NPs
can improve the permeability of insulin by opening the tight junctions between
intestinal epithelial cells and can protect insulin from the action of enzymes existing in
the gastrointestinal (GI) tract.
Nanoscience for Drug Delivery in Diabetes
Page: 70-101 (32)
Author: N. Vishal Gupta*, K. Trideva Sastri, M. Sharadha, Souvik Chakraborty, Hitesh Kumar, Vikas Jain and Surajit Dey
DOI: 10.2174/9789815196535123010007
PDF Price: $15
Abstract
Current conventional diabetes mellitus (DM) therapies are inadequate and
have poor patient compliance. Subsequently, it is necessary to explore nanomedicine in
managing diabetes. In recent years, several nanocarrier systems have been proven
effective in various aspects of diabetes treatment, increasing drug stability, overcoming
different biological barriers, and in enhancing bioavailability. Nanomedicine can
potentially improve the therapeutic effect of drug substances to gain the patient’s belief
and impart a greater level of acceptability. In the present scientific spectrum,
nanomedicines promise to provide sustained and targeted delivery with potential
physical stability for a prolonged period, rendering a safe and effective therapy for
diabetes. This chapter comprehensively elaborates on trends in the drug delivery
system in treating diabetes for improved delivery of different classes of antidiabetic
agents compared to contemporary therapies.
Nanoscience for Nucleotide Delivery in Diabetes
Page: 102-110 (9)
Author: Ali Rastegari*
DOI: 10.2174/9789815196535123010008
PDF Price: $15
Abstract
The convergence of nanoscience and nucleotide delivery holds tremendous
promise in revolutionizing diabetes treatment. Nucleotide delivery emerged as a
promising tool to modulate gene expression and cellular function in diabetes.
Integration of nanoscience and nucleotide delivery in diabetes treatment opens avenues
for efficient therapies. This approach has the potential to significantly improve glucose
regulation and mitigate long-term complications associated with the disease. This
chapter discussed DNA and RNA delivery approaches in diabetes treatment and the
future and challenges of nucleotide delivery in diabetes.
Introduction
Nanotechnology has shown immense promise for advancing blood glucose control. This technology offers the potential to safeguard pancreatic cells from autoimmune destruction by driving the creation of innovative therapeutic agents that can be delivered to specific targets. In this book, you will find a comprehensive exploration of diabetes and its approved medical treatments. The book delves into how nanotechnology can amplify the efficacy of current treatment modalities, potentially paving the way for a gene therapy solution to combat this disease. Starting with the history of diabetes treatment, the book explains treatment challenges for diabetes before getting into the three ways nanoscience is helping in diabetes treatment: insulin delivery, drug delivery and nucleotide delivery. Each chapter is contributed by accomplished experts in their respective fields, who strive to offer a thorough, yet accessible discussion of the subject.