In this chapter, the aim is to shed the light if the new era of stem cells can play a role in the field of Medical Parasitology. We will try to answer certain questions. First; would parasites be friends or foes in the process of stem cell culture and therapy? Another question is that; can stem cells be a novel therapy against the notorious parasites that attack the human being and heal the permanent damage that some parasites may induce in organs? Finally, could the parasite stem cells be a potential target for new anti-parasitic therapy, especially in resistant chronic debilitating parasitism?