Developmental and Stem Cell Biology in Health and Disease

Gene and Signals Regulating Stem Cell Fates

Author(s): Mohamed Berika, John Ku, Haifen Huang and Ahmed El-Hashash

Pp: 36-48 (13)

Doi: 10.2174/9781681082196116010005

* (Excluding Mailing and Handling)


Recent developments have revealed more about the signaling pathways governing hematopoietic stem cell (HSC) fate; several developmentally conserved pathways were identified, including Notch, Smad pathways, Sonic hedgehog (Shh), and Wingless-type (Wnt). These findings contribute to our understanding of HSC regulation and provide information of interactions within the bone marrow environment where HSCs reside. The signaling pathways that contribute to HSC regulation are further discussed in this chapter.

Keywords: Asymmetric divisions, Cell fate, Hematopoietic cells, Signaling pathway, Symmetric.

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